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Title: Radiation-Associated Liver Injury

The liver is a critically important organ that has numerous functions including the production of bile, metabolism of ingested nutrients, elimination of many waste products, glycogen storage, and plasma protein synthesis. The liver is often incidentally irradiated during radiation therapy (RT) for tumors in the upper- abdomen, right lower lung, distal esophagus, or during whole abdomen or whole body RT. This article describes the endpoints, time-course, and dose-volume effect of radiation on the liver.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [2] ;  [1]
  1. Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States)
  2. Department of Radiation Oncology, University of Colorado, Aurora, CO (United States)
  3. Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada)
  4. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)
  5. Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)
Publication Date:
OSTI Identifier:
21372136
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 76; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2009.06.092; PII: S0360-3016(09)03295-7; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABDOMEN; ESOPHAGUS; LIVER; NEOPLASMS; RADIATION INJURIES; RADIOTHERAPY BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DIGESTIVE SYSTEM; DISEASES; GLANDS; INJURIES; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY