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Title: External Beam Radiotherapy Plus 24-Hour Continuous Infusion of Gemcitabine in Unresectable Pancreatic Carcinoma: Long-Term Results of a Phase II Study

Purpose: To evaluate the efficacy of gemcitabine-based chemoradiation (CT-RT) in treating patients (pts) affected by locally advanced pancreatic cancers (LAPC). Methods and Materials: Weekly gemcitabine (100 mg/m{sup 2}) was given as a 24-hour infusion during the course of three-dimensional radiotherapy (50.4 Gy to the tumor, 39.6 Gy to the nodes). After CT-RT, pts received five cycles of sequential chemotherapy with gemcitabine (1000 mg/m{sup 2}; 1, 8, q21). Response rate was assessed according to World Health Organization criteria 6 weeks after the end of CT-RT. Local control (LC), time to progression (TTP), metastases-free survival (MFS), and overall survival (OS) were analyzed by the Kaplan Meier method. Results: Forty pts (male/female 22/18; median age 62 years, range, 36-76) were treated from 2000 to 2005. The majority had T4 tumour (n = 34, 85%), six pts (15%) had T3 tumour. Sixteen pts (40%) were node positive at diagnosis. Grade 3-4 acute toxicity was observed in 21 pts (52.5%). Thirty pts (75%) completed the treatment schedule. A clinical response was achieved in 12 pts (30%). With a median follow-up of 76 months (range, 32-98), 2-year LC was 39.6% (median, 12 months), 2-year TTP was 18.4% (median, 10 months), and 2-year MFS was 29.7% (median,more » 10 months). Two-year OS (25%; median, 15.5 months) compared with our previous study on 5-fluorouracil-based CT-RT (2.8%) was significantly improved (p <0.001). Conclusions: Gemcitabine CT-RT seems correlated with improved outcomes. Healthier patients who are likely to complete the treatment schedule may benefit most from this therapy.« less
Authors:
 [1] ;  [2] ;  [1] ;  [1] ;  [3] ; ;  [4] ;  [1] ;  [5] ; ; ;  [1] ;  [3] ;  [1]
  1. Department of Radiotherapy, Policlinico Universitario Agostino Gemelli, Catholic University, Rome (Italy)
  2. Department of Radiotherapy, John Paul II Center for High Technology Research and Education in Biomedical Sciences, Campobasso (Italy)
  3. Department of Digestive Surgery, Policlinico Universitario Agostino Gemelli, Catholic University, Rome (Italy)
  4. Department of Surgery, Policlinico Universitario Agostino Gemelli, Catholic University, Rome (Italy)
  5. Department of Medical Oncology, General Hospital, Isernia (Italy)
Publication Date:
OSTI Identifier:
21372108
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 76; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2009.02.013; PII: S0360-3016(09)00249-1; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTINEOPLASTIC DRUGS; CARCINOMAS; CHEMOTHERAPY; INFUSION; PANCREAS; RADIOTHERAPY BODY; DIGESTIVE SYSTEM; DISEASES; DRUGS; ENDOCRINE GLANDS; GLANDS; INTAKE; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; THERAPY