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Title: Gender, Race, and Survival: A Study in Non-Small-Cell Lung Cancer Brain Metastases Patients Utilizing the Radiation Therapy Oncology Group Recursive Partitioning Analysis Classification

Abstract

Purpose: To explore whether gender and race influence survival in non-small-cell lung cancer (NSCLC) in patients with brain metastases, using our large single-institution brain tumor database and the Radiation Therapy Oncology Group recursive partitioning analysis (RPA) brain metastases classification. Methods and materials: A retrospective review of a single-institution brain metastasis database for the interval January 1982 to September 2004 yielded 835 NSCLC patients with brain metastases for analysis. Patient subsets based on combinations of gender, race, and RPA class were then analyzed for survival differences. Results: Median follow-up was 5.4 months (range, 0-122.9 months). There were 485 male patients (M) (58.4%) and 346 female patients (F) (41.6%). Of the 828 evaluable patients (99%), 143 (17%) were black/African American (B) and 685 (83%) were white/Caucasian (W). Median survival time (MST) from time of brain metastasis diagnosis for all patients was 5.8 months. Median survival time by gender (F vs. M) and race (W vs. B) was 6.3 months vs. 5.5 months (p = 0.013) and 6.0 months vs. 5.2 months (p = 0.08), respectively. For patients stratified by RPA class, gender, and race, MST significantly favored BFs over BMs in Class II: 11.2 months vs. 4.6 months (p = 0.021). Onmore » multivariable analysis, significant variables were gender (p = 0.041, relative risk [RR] 0.83) and RPA class (p < 0.0001, RR 0.28 for I vs. III; p < 0.0001, RR 0.51 for II vs. III) but not race. Conclusions: Gender significantly influences NSCLC brain metastasis survival. Race trended to significance in overall survival but was not significant on multivariable analysis. Multivariable analysis identified gender and RPA classification as significant variables with respect to survival.« less

Authors:
 [1];  [1];  [2];  [3];  [4];  [3];  [4];  [1]
  1. Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH (United States)
  2. Department of Thoracic and Cardiovascular Surgery, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH (United States)
  3. Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH (United States)
  4. Brain Tumor and NeuroOncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH (United States)
Publication Date:
OSTI Identifier:
21367513
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 75; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2008.12.022; PII: S0360-3016(08)03918-7; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; LUNGS; METASTASES; MULTIVARIATE ANALYSIS; NEOPLASMS; RADIOTHERAPY; SURVIVAL TIME; BODY; CENTRAL NERVOUS SYSTEM; DISEASES; MATHEMATICS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RESPIRATORY SYSTEM; STATISTICS; THERAPY

Citation Formats

Videtic, Gregory M.M., E-mail: videtig@ccf.or, Reddy, Chandana A, Chao, Samuel T, Brain Tumor and NeuroOncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, Rice, Thomas W, Adelstein, David J, Barnett, Gene H, Department of Neurosurgery, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, Mekhail, Tarek M, Vogelbaum, Michael A, Department of Neurosurgery, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, Suh, John H, and Brain Tumor and NeuroOncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. Gender, Race, and Survival: A Study in Non-Small-Cell Lung Cancer Brain Metastases Patients Utilizing the Radiation Therapy Oncology Group Recursive Partitioning Analysis Classification. United States: N. p., 2009. Web. doi:10.1016/j.ijrobp.2008.12.022.
Videtic, Gregory M.M., E-mail: videtig@ccf.or, Reddy, Chandana A, Chao, Samuel T, Brain Tumor and NeuroOncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, Rice, Thomas W, Adelstein, David J, Barnett, Gene H, Department of Neurosurgery, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, Mekhail, Tarek M, Vogelbaum, Michael A, Department of Neurosurgery, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, Suh, John H, & Brain Tumor and NeuroOncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. Gender, Race, and Survival: A Study in Non-Small-Cell Lung Cancer Brain Metastases Patients Utilizing the Radiation Therapy Oncology Group Recursive Partitioning Analysis Classification. United States. https://doi.org/10.1016/j.ijrobp.2008.12.022
Videtic, Gregory M.M., E-mail: videtig@ccf.or, Reddy, Chandana A, Chao, Samuel T, Brain Tumor and NeuroOncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, Rice, Thomas W, Adelstein, David J, Barnett, Gene H, Department of Neurosurgery, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, Mekhail, Tarek M, Vogelbaum, Michael A, Department of Neurosurgery, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, Suh, John H, and Brain Tumor and NeuroOncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. 2009. "Gender, Race, and Survival: A Study in Non-Small-Cell Lung Cancer Brain Metastases Patients Utilizing the Radiation Therapy Oncology Group Recursive Partitioning Analysis Classification". United States. https://doi.org/10.1016/j.ijrobp.2008.12.022.
@article{osti_21367513,
title = {Gender, Race, and Survival: A Study in Non-Small-Cell Lung Cancer Brain Metastases Patients Utilizing the Radiation Therapy Oncology Group Recursive Partitioning Analysis Classification},
author = {Videtic, Gregory M.M., E-mail: videtig@ccf.or and Reddy, Chandana A and Chao, Samuel T and Brain Tumor and NeuroOncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH and Rice, Thomas W and Adelstein, David J and Barnett, Gene H and Department of Neurosurgery, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH and Mekhail, Tarek M and Vogelbaum, Michael A and Department of Neurosurgery, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH and Suh, John H and Brain Tumor and NeuroOncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH},
abstractNote = {Purpose: To explore whether gender and race influence survival in non-small-cell lung cancer (NSCLC) in patients with brain metastases, using our large single-institution brain tumor database and the Radiation Therapy Oncology Group recursive partitioning analysis (RPA) brain metastases classification. Methods and materials: A retrospective review of a single-institution brain metastasis database for the interval January 1982 to September 2004 yielded 835 NSCLC patients with brain metastases for analysis. Patient subsets based on combinations of gender, race, and RPA class were then analyzed for survival differences. Results: Median follow-up was 5.4 months (range, 0-122.9 months). There were 485 male patients (M) (58.4%) and 346 female patients (F) (41.6%). Of the 828 evaluable patients (99%), 143 (17%) were black/African American (B) and 685 (83%) were white/Caucasian (W). Median survival time (MST) from time of brain metastasis diagnosis for all patients was 5.8 months. Median survival time by gender (F vs. M) and race (W vs. B) was 6.3 months vs. 5.5 months (p = 0.013) and 6.0 months vs. 5.2 months (p = 0.08), respectively. For patients stratified by RPA class, gender, and race, MST significantly favored BFs over BMs in Class II: 11.2 months vs. 4.6 months (p = 0.021). On multivariable analysis, significant variables were gender (p = 0.041, relative risk [RR] 0.83) and RPA class (p < 0.0001, RR 0.28 for I vs. III; p < 0.0001, RR 0.51 for II vs. III) but not race. Conclusions: Gender significantly influences NSCLC brain metastasis survival. Race trended to significance in overall survival but was not significant on multivariable analysis. Multivariable analysis identified gender and RPA classification as significant variables with respect to survival.},
doi = {10.1016/j.ijrobp.2008.12.022},
url = {https://www.osti.gov/biblio/21367513}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 75,
place = {United States},
year = {Sun Nov 15 00:00:00 EST 2009},
month = {Sun Nov 15 00:00:00 EST 2009}
}