The Combination of Light and Stem Cell Therapies: A Novel Approach in Regenerative Medicine

Journal Article · Mon May 31 00:00:00 EDT 2010 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3453785· OSTI ID:21367314

Anders, Juanita; Moges, Helina; Wu, Xingjia ^[1]; Ilev, Ilko; Waynant, Ronald ^[2]; Longo, Leonardo ^[3]

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1. Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 (United States)
2. Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993 (United States)
3. Institute of Laser Medicine, University of Siena, Siena 53100 (Italy) and University of San Marino 47890 (San Marino)

Light therapy commonly referred to as low level laser therapy can alter cellular functions and clinical conditions. Some of the commonly reported in vitro and in vivo effects of light therapy include cellular proliferation, alterations in the inflammatory response to injury, and increases in mitochondrial respiration and adenosine triphosphate synthesis. Based on the known effects of light on cells and tissues in general and on reports in the last 5 years on the interaction of light with stem cells, evidence is mounting indicating that light therapy could greatly benefit stem cell regenerative medicine. Experiments on a variety of harvested adult stem cells demonstrate that light therapy enhances differentiation and proliferation of the cells and alters the expression of growth factors in a number of different types of adult stem cells and progenitors in vitro. It also has the potential to attenuate cytotoxic effects of drugs used to purge harvested autologous stem cells and to increase survival of transplanted cells.

• OSTI ID: 21367314
• Journal Information: AIP Conference Proceedings, Vol. 1226, Issue 1; Conference: 23. international congress laser medicine - Laser Florence 2009: A gallery through the laser medicine world, Florence (Italy), 6-7 Nov 2009; Other Information: DOI: 10.1063/1.3453785; (c) 2010 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

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