A flexible cold microplasma jet using biocompatible dielectric tubes for cancer therapy

Journal Article · Mon May 17 00:00:00 EDT 2010 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.3431392· OSTI ID:21347451

Kim, Jae Young; Kim, Sung-O ^[1]; Yanzhang, Wei; Jinhua, Li ^[2]

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1. Holcombe Department of Electrical and Computer Engineering, Center for Optical Materials Science and Engineering Technologies, Clemson University, Clemson, South Carolina 29634 (United States)
2. Department of Biological Sciences, Clemson University Biomedical Institute, Clemson University, Greenville, South Carolina 29605 (United States)

This paper describes a flexible microplasma jet device using a Tygon S-54-HL tube as a biocompatible tube and its potential in developing cancer therapies. The optical and physical properties of the plasma jets and preliminary apoptosis data of cultured murine tumor cells and nontumor fibroblast cells treated with these plasma jets are presented. Microplasma jets were observed to induce apoptosis in cultured murine cells in a dose-dependent manner. The murine melanoma tumor cells were more sensitive to plasma treatment than fibroblast cells. These features allow the direct and precise application of this microplasma jet device to tumor cells.

• OSTI ID: 21347451
• Journal Information: Applied Physics Letters, Vol. 96, Issue 20; Other Information: DOI: 10.1063/1.3431392; (c) 2010 American Institute of Physics; ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
APOPTOSIS
BIOPHYSICS
DIELECTRIC MATERIALS
FIBROBLASTS
MELANOMAS
PHYSICAL PROPERTIES
PLASMA
PLASMA JETS
THERAPY
TUMOR CELLS
ANIMAL CELLS
CARCINOMAS
CONNECTIVE TISSUE CELLS
DISEASES
EPITHELIOMAS
MATERIALS
MEDICINE
NEOPLASMS
PHYSICS
SOMATIC CELLS