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Title: Generation of Composite Dose and Biological Effective Dose (BED) Over Multiple Treatment Modalities and Multistage Planning Using Deformable Image Registration

Currently there are no commercially available tools to generate composite plans across different treatment modalities and/or different planning image sets. Without a composite plan, it may be difficult to perform a meaningful dosimetric evaluation of the overall treatment course. In this paper, we introduce a method to generate composite biological effective dose (BED) plans over multiple radiotherapy treatment modalities and/or multistage plans, using deformable image registration. Two cases were used to demonstrate the method. Case I was prostate cancer treated with intensity-modulated radiation therapy (IMRT) and a permanent seed implant. Case II involved lung cancer treated with two treatment plans generated on two separate computed tomography image sets. Thin-plate spline or optical flow methods were used as appropriate to generate deformation matrices. The deformation matrices were then applied to the dose matrices and the resulting physical doses were converted to BED and added to yield the composite plan. Cell proliferation and sublethal repair were considered in the BED calculations. The difference in BED between normal tissues and tumor volumes was accounted for by using different BED models, {alpha}/{beta} values, and cell potential doubling times. The method to generate composite BED plans presented in this paper provides information not available withmore » the traditional simple dose summation or physical dose summation. With the understanding of limitations and uncertainties of the algorithms involved, it may be valuable for the overall treatment plan evaluation.« less
Authors:
 [1] ; ; ; ;  [2]
  1. Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL (United States) and Department of Medical Radiological Technology, China Medical University, Taiwan (China), E-mail: geoffrey.zhang@moffitt.org
  2. Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL (United States) and Department of Medical Radiological Technology, China Medical University, Taiwan (China)
Publication Date:
OSTI Identifier:
21333982
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Dosimetry; Journal Volume: 35; Journal Issue: 2; Other Information: DOI: 10.1016/j.meddos.2009.05.001; PII: S0958-3947(09)00048-X; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; BIOLOGICAL REPAIR; CELL PROLIFERATION; COMPUTERIZED TOMOGRAPHY; IMAGES; LUNGS; NEOPLASMS; PLANNING; PROSTATE; RADIATION DOSES; RADIOTHERAPY