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Title: Measurement of Interfraction Variations in Position and Size of Target Volumes in Stereotactic Body Radiotherapy for Lung Cancer

Abstract

Purpose: To investigate the interfraction variations in volume, motion range, and position of the gross tumor volume (GTV) in hypofractionated stereotactic body radiotherapy (SBRT) for lung cancer using four-dimensional computed tomography. Methods and Materials: Four-dimensional computed tomography scans were acquired for 8 patients once at treatment planning and twice during the SBRT period using a stereotactic body frame. The image registration was performed to correct setup errors for clinical four-dimensional computed tomography. The interfraction variations in volume, motion range, and position of GTV were computed at end-inhalation (EI) and end-exhalation (EE). Results: The random variations in the GTV were 0.59 cm{sup 3} at EI and 0.53 cm{sup 3} at EE, and the systematic variations were 3.04 cm{sup 3} at EI and 3.21 cm{sup 3} at EE. No significant variations in GTV were found during the SBRT sessions (p = .301 at EI and p = .081 at EE). The random variations in GTV motion range for the upper lobe in the craniocaudal direction were within 1.0 mm and for the lower lobe was 3.4 mm. The interfraction variations in the GTV centroid position in the anteroposterior and craniocaudal directions were mostly larger than in the right-left direction; however, no significantmore » displacement was observed among the sessions in any direction. Conclusion: For patients undergoing hypofractionated SBRT, interfraction variations in GTV, motion range, and position mainly remained small. An additional approach is needed to assess the margin size.« less

Authors:
 [1];  [1]; ; ; ; ; ; ; ;  [1]
  1. Department of Radiation Oncology and Image-Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto (Japan)
Publication Date:
OSTI Identifier:
21282059
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 75; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2008.12.091; PII: S0360-3016(09)00843-8; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMPUTERIZED TOMOGRAPHY; EXHALATION; IMAGES; INHALATION; LUNGS; NEOPLASMS; PATIENTS; PLANNING; RADIOTHERAPY

Citation Formats

Matsugi, Kiyotomo, Narita, Yuichiro, Sawada, Akira, Nakamura, Mitsuhiro, Miyabe, Yuki, Matsuo, Yukinori, Narabayashi, Masaru, Norihisa, Yoshiki, Mizowaki, Takashi, and Hiraoka, Masahiro. Measurement of Interfraction Variations in Position and Size of Target Volumes in Stereotactic Body Radiotherapy for Lung Cancer. United States: N. p., 2009. Web. doi:10.1016/j.ijrobp.2008.12.091.
Matsugi, Kiyotomo, Narita, Yuichiro, Sawada, Akira, Nakamura, Mitsuhiro, Miyabe, Yuki, Matsuo, Yukinori, Narabayashi, Masaru, Norihisa, Yoshiki, Mizowaki, Takashi, & Hiraoka, Masahiro. Measurement of Interfraction Variations in Position and Size of Target Volumes in Stereotactic Body Radiotherapy for Lung Cancer. United States. https://doi.org/10.1016/j.ijrobp.2008.12.091
Matsugi, Kiyotomo, Narita, Yuichiro, Sawada, Akira, Nakamura, Mitsuhiro, Miyabe, Yuki, Matsuo, Yukinori, Narabayashi, Masaru, Norihisa, Yoshiki, Mizowaki, Takashi, and Hiraoka, Masahiro. 2009. "Measurement of Interfraction Variations in Position and Size of Target Volumes in Stereotactic Body Radiotherapy for Lung Cancer". United States. https://doi.org/10.1016/j.ijrobp.2008.12.091.
@article{osti_21282059,
title = {Measurement of Interfraction Variations in Position and Size of Target Volumes in Stereotactic Body Radiotherapy for Lung Cancer},
author = {Matsugi, Kiyotomo and Narita, Yuichiro and Sawada, Akira and Nakamura, Mitsuhiro and Miyabe, Yuki and Matsuo, Yukinori and Narabayashi, Masaru and Norihisa, Yoshiki and Mizowaki, Takashi and Hiraoka, Masahiro},
abstractNote = {Purpose: To investigate the interfraction variations in volume, motion range, and position of the gross tumor volume (GTV) in hypofractionated stereotactic body radiotherapy (SBRT) for lung cancer using four-dimensional computed tomography. Methods and Materials: Four-dimensional computed tomography scans were acquired for 8 patients once at treatment planning and twice during the SBRT period using a stereotactic body frame. The image registration was performed to correct setup errors for clinical four-dimensional computed tomography. The interfraction variations in volume, motion range, and position of GTV were computed at end-inhalation (EI) and end-exhalation (EE). Results: The random variations in the GTV were 0.59 cm{sup 3} at EI and 0.53 cm{sup 3} at EE, and the systematic variations were 3.04 cm{sup 3} at EI and 3.21 cm{sup 3} at EE. No significant variations in GTV were found during the SBRT sessions (p = .301 at EI and p = .081 at EE). The random variations in GTV motion range for the upper lobe in the craniocaudal direction were within 1.0 mm and for the lower lobe was 3.4 mm. The interfraction variations in the GTV centroid position in the anteroposterior and craniocaudal directions were mostly larger than in the right-left direction; however, no significant displacement was observed among the sessions in any direction. Conclusion: For patients undergoing hypofractionated SBRT, interfraction variations in GTV, motion range, and position mainly remained small. An additional approach is needed to assess the margin size.},
doi = {10.1016/j.ijrobp.2008.12.091},
url = {https://www.osti.gov/biblio/21282059}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 75,
place = {United States},
year = {Thu Oct 01 00:00:00 EDT 2009},
month = {Thu Oct 01 00:00:00 EDT 2009}
}