Stereotactic Body Radiotherapy Is Effective Salvage Therapy for Patients With Prior Radiation of Spinal Metastases
- Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (United States)
- Department of Neurologic Surgery, University of California San Francisco, San Francisco, CA (United States)
- Department of Epidemiology, University of Toronto, Princess Margaret Hospital, Toronto, ON (Canada)
- Department of Radiology, University of California San Francisco, San Francisco, CA (United States)
- UCSF Helen Diller Family Comprehensive Cancer Center Biostatistics Core, University of California San Francisco, San Francisco, CA (United States)
Purpose: To provide actuarial outcomes and dosimetric data for spinal/paraspinal metastases, with and without prior radiation, treated with stereotactic body radiotherapy (SBRT). Methods and Materials: A total of 39 consecutive patients (60 metastases) were treated with SBRT between April 2003 and August 2006 and retrospectively reviewed. In all, 23 of 60 tumors had no previous radiation (unirradiated) and 37/60 tumors had previous irradiation (reirradiated). Of 37 reirradiated tumors, 31 were treated for 'salvage' given image-based tumor progression. Local failure was defined as progression by imaging and/or clinically. Results: At last follow-up, 19 patients were deceased. Median patient survival time measured was 21 months (95% CI = 8-27 months), and the 2-year survival probability was 45%. The median total dose prescribed was 24 Gy in three fractions prescribed to the 67% and 60% isodose for the unirradiated and reirradiated cohorts, respectively. The median tumor follow-up for the unirradiated and reirradiated group was 9 months (range, 1-26) and 7 months (range, 1-48) respectively. Eight of 60 tumors have progressed, and the 1- and 2-year progression-free probability (PFP) was 85% and 69%, respectively. For the salvage group the 1 year PFP was 96%. There was no significant difference in overall survival or PFP between the salvage reirradiated vs. all other tumors treated (p = 0.08 and p = 0.31, respectively). In six of eight failures the minimum distance from the tumor to the thecal sac was {<=}1 mm. Of 60 tumors treated, 39 have {>=}6 months follow-up and no radiation-induced myelopathy or radiculopathy has occurred. Conclusion: Spine SBRT has shown preliminary efficacy and safety in patients with image-based progression of previously irradiated metastases.
- OSTI ID:
- 21276856
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 74, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2008.09.020; PII: S0360-3016(08)03500-1; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
Similar Records
Impact of Dose on Local Failure Rates After Image-Guided Reirradiation of Recurrent Paraspinal Metastases
Multifractionated image-guided and stereotactic intensity-modulated radiotherapy of paraspinal tumors: A preliminary report