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Title: Impaired arsenic metabolism in children during weaning

Background: Methylation of inorganic arsenic (iAs) via one-carbon metabolism is a susceptibility factor for a range of arsenic-related health effects, but there is no data on the importance of arsenic metabolism for effects on child development. Aim: To elucidate the development of arsenic metabolism in early childhood. Methods: We measured iAs, methylarsonic acid (MA) and dimethylarsinic acid (DMA), the metabolites of iAs, in spot urine samples of 2400 children at 18 months of age. The children were born to women participating in a population-based longitudinal study of arsenic effects on pregnancy outcomes and child development, carried out in Matlab, a rural area in Bangladesh with a wide range of arsenic concentrations in drinking water. Arsenic metabolism was evaluated in relation to age, sex, anthropometry, socio-economic status and arsenic exposure. Results: Arsenic concentrations in child urine (median 34 {mu}g/L, range 2.4-940 {mu}g/L), adjusted to average specific gravity of 1.009 g/mL, were considerably higher than that measured at 3 months of age, but lower than that in maternal urine. Child urine contained on average 12% iAs, 9.4% MA and 78% DMA, which implies a marked change in metabolite pattern since infancy. In particular, there was a marked increase in urinary %MA, whichmore » has been associated with increased risk of health effects. Conclusion: The arsenic metabolite pattern in urine of children at 18 months of age in rural Bangladesh indicates a marked decrease in arsenic methylation efficiency during weaning.« less
Authors:
 [1] ;  [2] ; ; ;  [1] ;  [3]
  1. Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm (Sweden)
  2. ICDDR-B: International Centre for Diarrhoeal Disease Research (Bangladesh)
  3. Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm (Sweden), E-mail: marie.vahter@ki.se
Publication Date:
OSTI Identifier:
21272645
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicology and Applied Pharmacology; Journal Volume: 239; Journal Issue: 2; Conference: Valencia Spain arsenic meeting: From nature to humans, Valencia (Spain), 21-23 May 2008; Other Information: DOI: 10.1016/j.taap.2008.12.019; PII: S0041-008X(08)00530-9; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ARSENIC; CHILDREN; DENSITY; DRINKING WATER; METABOLISM; METABOLITES; METHYLATION; RURAL AREAS; URINE