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Title: Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

Abstract

Capsaicin is widely used as a food additive and as an analgesic agent. Besides its well-known role in nociception, which is mediated by vanilloid receptor 1 specifically expressed in dorsal root ganglion neurons, capsaicin has also been considered as a potential anticancer agent, as it inhibits cell proliferation and induces apoptosis in various types of cancer cells. Here we identified a new molecular target of capsaicin from human myeloid leukemia cells. We show that capsaicin binds to prohibitin (PHB) 2, which is normally localized to the inner mitochondrial membrane, and induces its translocation to the nucleus. PHB2 is implicated in the maintenance of mitochondrial morphology and the control of apoptosis. We also provide evidence suggesting that capsaicin causes apoptosis directly through the mitochondria and that PHB2 contributes to capsaicin-induced apoptosis at multiple levels. This work will serve as an important foundation for further understanding of anticancer activity of capsaicin.

Authors:
; ; ; ; ;  [1];  [2];  [1];  [3];  [2];  [1]
  1. Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama (Japan)
  2. Department of Integrative Medical Biology, School of Medicine, Keio University, Tokyo (Japan)
  3. Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama (Japan)
Publication Date:
OSTI Identifier:
21255871
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 379; Journal Issue: 2; Other Information: DOI: 10.1016/j.bbrc.2008.12.103; PII: S0006-291X(08)02510-2; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANALGESICS; APOPTOSIS; CELL PROLIFERATION; FOOD ADDITIVES; GANGLIONS; MEMBRANES; MITOCHONDRIA; MORPHOLOGY; MYELOID LEUKEMIA; NERVE CELLS; RECEPTORS; TRANSLOCATION

Citation Formats

Kuramori, Chikanori, Azuma, Motoki, Kume, Kanako, Kaneko, Yuki, Inoue, Atsushi, Yamaguchi, Yuki, Kabe, Yasuaki, Hosoya, Takamitsu, Kizaki, Masahiro, Suematsu, Makoto, Handa, Hiroshi, and Integrated Research Institute, Tokyo Institute of Technology, Yokohama. Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus. United States: N. p., 2009. Web. doi:10.1016/j.bbrc.2008.12.103.
Kuramori, Chikanori, Azuma, Motoki, Kume, Kanako, Kaneko, Yuki, Inoue, Atsushi, Yamaguchi, Yuki, Kabe, Yasuaki, Hosoya, Takamitsu, Kizaki, Masahiro, Suematsu, Makoto, Handa, Hiroshi, & Integrated Research Institute, Tokyo Institute of Technology, Yokohama. Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus. United States. https://doi.org/10.1016/j.bbrc.2008.12.103
Kuramori, Chikanori, Azuma, Motoki, Kume, Kanako, Kaneko, Yuki, Inoue, Atsushi, Yamaguchi, Yuki, Kabe, Yasuaki, Hosoya, Takamitsu, Kizaki, Masahiro, Suematsu, Makoto, Handa, Hiroshi, and Integrated Research Institute, Tokyo Institute of Technology, Yokohama. 2009. "Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus". United States. https://doi.org/10.1016/j.bbrc.2008.12.103.
@article{osti_21255871,
title = {Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus},
author = {Kuramori, Chikanori and Azuma, Motoki and Kume, Kanako and Kaneko, Yuki and Inoue, Atsushi and Yamaguchi, Yuki and Kabe, Yasuaki and Hosoya, Takamitsu and Kizaki, Masahiro and Suematsu, Makoto and Handa, Hiroshi and Integrated Research Institute, Tokyo Institute of Technology, Yokohama},
abstractNote = {Capsaicin is widely used as a food additive and as an analgesic agent. Besides its well-known role in nociception, which is mediated by vanilloid receptor 1 specifically expressed in dorsal root ganglion neurons, capsaicin has also been considered as a potential anticancer agent, as it inhibits cell proliferation and induces apoptosis in various types of cancer cells. Here we identified a new molecular target of capsaicin from human myeloid leukemia cells. We show that capsaicin binds to prohibitin (PHB) 2, which is normally localized to the inner mitochondrial membrane, and induces its translocation to the nucleus. PHB2 is implicated in the maintenance of mitochondrial morphology and the control of apoptosis. We also provide evidence suggesting that capsaicin causes apoptosis directly through the mitochondria and that PHB2 contributes to capsaicin-induced apoptosis at multiple levels. This work will serve as an important foundation for further understanding of anticancer activity of capsaicin.},
doi = {10.1016/j.bbrc.2008.12.103},
url = {https://www.osti.gov/biblio/21255871}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 2,
volume = 379,
place = {United States},
year = {Fri Feb 06 00:00:00 EST 2009},
month = {Fri Feb 06 00:00:00 EST 2009}
}