SUMOylation of ROR{alpha} potentiates transcriptional activation function
Abstract
SUMOylation regulates a variety of cellular processes, including control of transcriptional activities of nuclear receptors. Here, we present SUMOylation of orphan nuclear receptor, ROR{alpha} by both SUMO-1 and SUMO-2. SUMOylation of ROR{alpha} occurred on the 240th lysine residue at the hinge region of human protein. PIAS family members, PIASx{alpha}, PIAS3, and PIASy, increased SUMOylation of ROR{alpha}, whereas SENP2 specifically removed SUMO from ROR{alpha}. SUMOylation-defective mutant form of ROR{alpha} exhibited decreased transcriptional activity on ROR{alpha}-responsive promoters indicating that SUMOylation may positively regulate transcriptional function of ROR{alpha}.
- Authors:
-
- Department of Biological Sciences, Research Center for Women's Disease, Sookmyung Women's University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742 (Korea, Republic of)
- Department of Biological Sciences, Seoul National University, Seoul 151-742 (Korea, Republic of)
- Department of Medical Sciences, Inha University, Incheon 402-751 (Korea, Republic of)
- Publication Date:
- OSTI Identifier:
- 21255836
- Resource Type:
- Journal Article
- Journal Name:
- Biochemical and Biophysical Research Communications
- Additional Journal Information:
- Journal Volume: 378; Journal Issue: 3; Other Information: DOI: 10.1016/j.bbrc.2008.11.072; PII: S0006-291X(08)02271-7; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; HUMAN POPULATIONS; LEUKEMIA; LYSINE; MUTANTS; PROMOTERS; RECEPTORS; RETINOIC ACID
Citation Formats
Hwang, Eun Ju, Lee, Ji Min, Jeong, Jiyeong, Park, Joo Hyeon, Yang, Young, Lim, Jong-Seok, Kim, Jung Hwa, Baek, Sung Hee, and Kim, Keun Il. SUMOylation of ROR{alpha} potentiates transcriptional activation function. United States: N. p., 2009.
Web. doi:10.1016/j.bbrc.2008.11.072.
Hwang, Eun Ju, Lee, Ji Min, Jeong, Jiyeong, Park, Joo Hyeon, Yang, Young, Lim, Jong-Seok, Kim, Jung Hwa, Baek, Sung Hee, & Kim, Keun Il. SUMOylation of ROR{alpha} potentiates transcriptional activation function. United States. https://doi.org/10.1016/j.bbrc.2008.11.072
Hwang, Eun Ju, Lee, Ji Min, Jeong, Jiyeong, Park, Joo Hyeon, Yang, Young, Lim, Jong-Seok, Kim, Jung Hwa, Baek, Sung Hee, and Kim, Keun Il. 2009.
"SUMOylation of ROR{alpha} potentiates transcriptional activation function". United States. https://doi.org/10.1016/j.bbrc.2008.11.072.
@article{osti_21255836,
title = {SUMOylation of ROR{alpha} potentiates transcriptional activation function},
author = {Hwang, Eun Ju and Lee, Ji Min and Jeong, Jiyeong and Park, Joo Hyeon and Yang, Young and Lim, Jong-Seok and Kim, Jung Hwa and Baek, Sung Hee and Kim, Keun Il},
abstractNote = {SUMOylation regulates a variety of cellular processes, including control of transcriptional activities of nuclear receptors. Here, we present SUMOylation of orphan nuclear receptor, ROR{alpha} by both SUMO-1 and SUMO-2. SUMOylation of ROR{alpha} occurred on the 240th lysine residue at the hinge region of human protein. PIAS family members, PIASx{alpha}, PIAS3, and PIASy, increased SUMOylation of ROR{alpha}, whereas SENP2 specifically removed SUMO from ROR{alpha}. SUMOylation-defective mutant form of ROR{alpha} exhibited decreased transcriptional activity on ROR{alpha}-responsive promoters indicating that SUMOylation may positively regulate transcriptional function of ROR{alpha}.},
doi = {10.1016/j.bbrc.2008.11.072},
url = {https://www.osti.gov/biblio/21255836},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 3,
volume = 378,
place = {United States},
year = {Fri Jan 16 00:00:00 EST 2009},
month = {Fri Jan 16 00:00:00 EST 2009}
}
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