skip to main content

Title: Effect of Rosiglitazone on Radiation Damage in Bone Marrow Hemopoiesis

To study radiobiological effects and drugs, which can modify radiation injury, has an importance if we would like to avoid harmful effects of radiation due to emergency situations or treat patients with malignant diseases by radiotherapy. During the long treatment schedules patients may be treated by not only anticancer but many other drugs because of accompanying diseases. These drugs may also modify radiobiological effects. Rosiglitazone pre-treatment proved to be myeloprotective and accelerated recovery of 5-fluorouracil-damaged bone marrow in our previous experiments. Our new studies are designed to evaluate whether rosiglitazone has similar beneficial effects in radiation-damaged hemopoiesis. Bone marrow damage was precipitated by total body irradiation (TBI) using single increasing doses (2-10 Gy) of {gamma}--irradiation in groups of mice. Lethality was well correlated with damage in hemopoiesis measured by cellularity of bone marrow (LD{sub 50} values were 4.8 and 5.3 gray respectively). Rosiglitazone, an insulin-sensitizing drug, had no significant effect on bone marrow cellularity. Insulin resistance associated with obesity or diabetes mellitus type 2 is intensively growing among cancer patients requiring some kind of radiotherapy. Therefore it is important to know whether drugs used for their therapy can modify radiation effects.
Authors:
 [1] ;  [2] ; ; ; ;  [3]
  1. Euromedic Diagnostics Szeged LtD, Medical and Health Science Center, University of Debrecen (Hungary)
  2. Department of Radiotherapy, Medical and Health Science Center, University of Debrecen (Hungary)
  3. Department of Pharmacology and Pharmacotherapy, Medical and Health Science Center, University of Debrecen, Nagyerdei bld. 98., H-4032 Debrecen (Hungary)
Publication Date:
OSTI Identifier:
21254916
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1080; Journal Issue: 1; Conference: RADAM 2008: 5. international conference on radiation damage in biomolecular systems, Debrecen (Hungary), 13-15 Jun 2008; Other Information: DOI: 10.1063/1.3058979; (c) 2008 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD FORMATION; BONE MARROW; DIABETES MELLITUS; DNA; DRUGS; GAMMA RADIATION; INSULIN; MICE; MONTE CARLO METHOD; NEOPLASMS; PATIENTS; RADIATION DOSE UNITS; RADIATION INJURIES; RADIOTHERAPY; URACILS; WHOLE-BODY IRRADIATION