Layered double hydroxides as supports for intercalation and sustained release of antihypertensive drugs

Journal Article · Wed Oct 15 00:00:00 EDT 2008 · Journal of Solid State Chemistry

OSTI ID:21212039

Shengjie, Xia ^[1]; Qian, Xu; Baoxiang, Hu; Jun, Hu ^[1]

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1. College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032 (China)

Zn/Al layered double hydroxides (LDHs) were intercalated with the anionic antihypertensive drugs Enalpril, Lisinopril, Captopril and Ramipril by using coprecipitation or ion-exchange technique. TG-MS analyses suggested that the thermal stability of Ena{sup -}, Lis{sup -} (arranged with monolayer, resulted from X-ray diffraction (XRD) and Fourier transform infrared spectra (FT-IR) analysis was enhanced much more than Cap{sup -} and Ram{sup -} (arranged with bilayer). The release studies show that the release rate of all samples markedly decreased in both pH 4.25 and 7.45. However, the release time of Ena{sup -}, Lis{sup -} were much longer compared with Cap{sup -}, Ram{sup -} in both pH 4.25 and 7.45, it is possible that the intercalated guests, arranged with monolayer in the interlayer, show lesser repulsive force and strong affinity with the LDH layers. And the release data followed both the Higuchi-square-root law and the first-order equation well. Based on the analysis of batch release, intercalated structural models as well as the TG-DTA results, we conclude that for drug-LDH, stronger the affinity between intercalated anions and the layers is, better the thermal property and the stability to the acid attack of drug-LDH, and the intercalated anions are easier apt to monolayer arrangement within the interlayer, were presented. - Graphical abstract: A series of antihypertensive drugs including Enalpril, Lisinopril, Captopril and Ramipril were intercalated into Zn/Al-NO{sub 3}-LDHs successfully by coprecipitation or ion-exchange technique. We focus on the structure, thermal property and low/controlled release property of as-synthesized drug-LDH composite intended for the possibility of applying these LDH-antihypertensive nanohybrids in drug delivery and controlled release systems.

• OSTI ID: 21212039
• Journal Information: Journal of Solid State Chemistry, Vol. 181, Issue 10; Other Information: DOI: 10.1016/j.jssc.2008.06.009; PII: S0022-4596(08)00297-1; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0022-4596
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
AFFINITY
ALUMINIUM HYDROXIDES
ALUMINIUM NITRATES
ANTIHYPERTENSIVE AGENTS
COPRECIPITATION
DIFFERENTIAL THERMAL ANALYSIS
FOURIER TRANSFORMATION
INFRARED SPECTRA
ION EXCHANGE
LAYERS
NITROGEN OXIDES
PH VALUE
STABILITY
STRUCTURAL MODELS
THERMODYNAMIC PROPERTIES
X-RAY DIFFRACTION
ZINC
ZINC HYDROXIDES