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Title: Papillomavirus E6 proteins

The papillomaviruses are small DNA viruses that encode approximately eight genes, and require the host cell DNA replication machinery for their viral DNA replication. Thus papillomaviruses have evolved strategies to induce host cell DNA synthesis balanced with strategies to protect the cell from unscheduled replication. While the papillomavirus E1 and E2 genes are directly involved in viral replication by binding to and unwinding the origin of replication, the E6 and E7 proteins have auxillary functions that promote proliferation. As a consequence of disrupting the normal checkpoints that regulate cell cycle entry and progression, the E6 and E7 proteins play a key role in the oncogenic properties of human papillomaviruses with a high risk of causing anogenital cancers (HR HPVs). As a consequence, E6 and E7 of HR HPVs are invariably expressed in cervical cancers. This article will focus on the E6 protein and its numerous activities including inactivating p53, blocking apoptosis, activating telomerase, disrupting cell adhesion, polarity and epithelial differentiation, altering transcription and reducing immune recognition.
Authors:
 [1] ;  [1] ;  [2] ;  [3]
  1. Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C1-015, Box 19024, Seattle, WA 98109-1024 (United States)
  2. (United States)
  3. Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C1-015, Box 19024, Seattle, WA 98109-1024 (United States), E-mail: dgallowa@fhcrc.org
Publication Date:
OSTI Identifier:
21182804
Resource Type:
Journal Article
Resource Relation:
Journal Name: Virology; Journal Volume: 384; Journal Issue: 2; Other Information: DOI: 10.1016/j.virol.2008.11.017; PII: S0042-6822(08)00725-3; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ADHESION; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; DNA; DNA REPLICATION; HOST; NEOPLASMS; ONCOGENES; PROTEINS; SYNTHESIS; TRANSCRIPTION; VIRUSES