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Title: Longitudinal study to assess the safety and efficacy of a live-attenuated SHIV vaccine in long term immunized rhesus macaques

Abstract

Live-attenuated viruses derived from SIV and SHIV have provided the most consistent protection against challenge with pathogenic viruses, but concerns regarding their long-term safety and efficacy have hampered their clinical usefulness. We report a longitudinal study in which we evaluated the long-term safety and efficacy of {delta}vpuSHIV{sub PPC}, a live virus vaccine derived from SHIV{sub PPC}. Macaques were administered two inoculations of {delta}vpuSHIV{sub PPC}, three years apart, and followed for eight years. None of the five vaccinated macaques developed an AIDS-like disease from the vaccine. At eight years, macaques were challenged with pathogenic SIV and SHIV. None of the four macaques with detectable cellular-mediated immunity prior to challenge had detectable viral RNA in the plasma. This study demonstrates that multiple inoculations of a live vaccine virus can be used safely and can significantly extend the efficacy of the vaccine, as compared to a single inoculation, which is efficacious for approximately three years.

Authors:
; ; ; ;  [1];  [1];  [1]
  1. Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, 3025 WHW - MS 3029, 3901 Rainbow Boulevard, Kansas City, KS 66160 (United States)
Publication Date:
OSTI Identifier:
21182794
Resource Type:
Journal Article
Journal Name:
Virology
Additional Journal Information:
Journal Volume: 383; Journal Issue: 1; Other Information: DOI: 10.1016/j.virol.2008.09.038; PII: S0042-6822(08)00630-2; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0042-6822
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; AIDS; IMMUNITY; INOCULATION; RNA; SAFETY; VACCINES; VIRUSES

Citation Formats

Yankee, Thomas M., Sheffer, Darlene, Zhengian, Liu, Dhillon, Sukhbir, Fenglan, Jia, Chebloune, Yahia, Stephens, Edward B, Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, and Narayan, Opendra. Longitudinal study to assess the safety and efficacy of a live-attenuated SHIV vaccine in long term immunized rhesus macaques. United States: N. p., 2009. Web. doi:10.1016/j.virol.2008.09.038.
Yankee, Thomas M., Sheffer, Darlene, Zhengian, Liu, Dhillon, Sukhbir, Fenglan, Jia, Chebloune, Yahia, Stephens, Edward B, Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, & Narayan, Opendra. Longitudinal study to assess the safety and efficacy of a live-attenuated SHIV vaccine in long term immunized rhesus macaques. United States. https://doi.org/10.1016/j.virol.2008.09.038
Yankee, Thomas M., Sheffer, Darlene, Zhengian, Liu, Dhillon, Sukhbir, Fenglan, Jia, Chebloune, Yahia, Stephens, Edward B, Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, and Narayan, Opendra. 2009. "Longitudinal study to assess the safety and efficacy of a live-attenuated SHIV vaccine in long term immunized rhesus macaques". United States. https://doi.org/10.1016/j.virol.2008.09.038.
@article{osti_21182794,
title = {Longitudinal study to assess the safety and efficacy of a live-attenuated SHIV vaccine in long term immunized rhesus macaques},
author = {Yankee, Thomas M. and Sheffer, Darlene and Zhengian, Liu and Dhillon, Sukhbir and Fenglan, Jia and Chebloune, Yahia and Stephens, Edward B and Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160 and Narayan, Opendra},
abstractNote = {Live-attenuated viruses derived from SIV and SHIV have provided the most consistent protection against challenge with pathogenic viruses, but concerns regarding their long-term safety and efficacy have hampered their clinical usefulness. We report a longitudinal study in which we evaluated the long-term safety and efficacy of {delta}vpuSHIV{sub PPC}, a live virus vaccine derived from SHIV{sub PPC}. Macaques were administered two inoculations of {delta}vpuSHIV{sub PPC}, three years apart, and followed for eight years. None of the five vaccinated macaques developed an AIDS-like disease from the vaccine. At eight years, macaques were challenged with pathogenic SIV and SHIV. None of the four macaques with detectable cellular-mediated immunity prior to challenge had detectable viral RNA in the plasma. This study demonstrates that multiple inoculations of a live vaccine virus can be used safely and can significantly extend the efficacy of the vaccine, as compared to a single inoculation, which is efficacious for approximately three years.},
doi = {10.1016/j.virol.2008.09.038},
url = {https://www.osti.gov/biblio/21182794}, journal = {Virology},
issn = {0042-6822},
number = 1,
volume = 383,
place = {United States},
year = {Mon Jan 05 00:00:00 EST 2009},
month = {Mon Jan 05 00:00:00 EST 2009}
}