Epstein-Barr virus growth/latency III program alters cellular microRNA expression
- Louisiana Cancer Research Consortium, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL79, New Orleans, LA 70112 (United States)
- Department of Pathology, Tulane University Health Sciences Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL79, New Orleans, LA 70112 (United States)
The Epstein-Barr virus (EBV) is associated with lymphoid and epithelial cancers. Initial EBV infection alters lymphocyte gene expression, inducing cellular proliferation and differentiation as the virus transitions through consecutive latency transcription programs. Cellular microRNAs (miRNAs) are important regulators of signaling pathways and are implicated in carcinogenesis. The extent to which EBV exploits cellular miRNAs is unknown. Using micro-array analysis and quantitative PCR, we demonstrate differential expression of cellular miRNAs in type III versus type I EBV latency including elevated expression of miR-21, miR-23a, miR-24, miR-27a, miR-34a, miR-146a and b, and miR-155. In contrast, miR-28 expression was found to be lower in type III latency. The EBV-mediated regulation of cellular miRNAs may contribute to EBV signaling and associated cancers.
- OSTI ID:
- 21182790
- Journal Information:
- Virology, Vol. 382, Issue 2; Other Information: DOI: 10.1016/j.virol.2008.09.018; PII: S0042-6822(08)00602-8; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0042-6822
- Country of Publication:
- United States
- Language:
- English
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