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Title: Effect of {sup 11}C-Methionine-Positron Emission Tomography on Gross Tumor Volume Delineation in Stereotactic Radiotherapy of Skull Base Meningiomas

Purpose: To evaluate the effect of trimodal image fusion using computed tomography (CT), magnetic resonance imaging (MRI) and {sup 11}C-methionine positron emission tomography (MET-PET) for gross tumor volume delineation in fractionated stereotactic radiotherapy of skull base meningiomas. Patients and Methods: In 32 patients with skull base meningiomas, the gross tumor volume (GTV) was outlined on CT scans fused to contrast-enhanced MRI (GTV-MRI/CT). A second GTV, encompassing the MET-PET positive region only (GTV-PET), was generated. The additional information obtained by MET-PET concerning the GTV delineation was evaluated using the PET/CT/MRI co-registered images. The sizes of the overlapping regions of GTV-MRI/CT and GTV-PET were calculated and the amounts of additional volumes added by the complementing modality determined. Results: The addition of MET-PET was beneficial for GTV delineation in all but 3 patients. MET-PET detected small tumor portions with a mean volume of 1.6 {+-} 1.7 cm{sup 3} that were not identified by CT or MRI. The mean percentage of enlargement of the GTV using MET-PET as an additional imaging method was 9.4% {+-} 10.7%. Conclusions: Our data have demonstrated that integration of MET-PET in radiotherapy planning of skull base meningiomas can influence the GTV, possibly resulting in an increase, as well asmore » in a decrease.« less
Authors:
 [1] ;  [2] ; ;  [3] ;  [2] ;  [3] ;  [2] ;  [4] ;  [5]
  1. Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany), E-mail: sabrina.astner@gmx.de
  2. Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany)
  3. Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany)
  4. Department of Radiation Oncology, University of Freiburg, Freiburg (Germany)
  5. Department of Nuclear Medicine, University of Freiburg, Freiburg (Germany)
Publication Date:
OSTI Identifier:
21172470
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 72; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2008.02.058; PII: S0360-3016(08)00425-2; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; CARBON 11; COMPUTERIZED TOMOGRAPHY; IMAGES; METHIONINE; NEOPLASMS; NMR IMAGING; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; RADIOTHERAPY; SKULL