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Title: Curcumin prevents human dendritic cell response to immune stimulants

Curcumin, a compound found in the Indian spice turmeric, has anti-inflammatory and immunomodulatory properties, though the mechanism remains unclear. Dendritic cells (DCs) are important to generating an immune response and the effect of curcumin on human DCs has not been explored. The role curcumin in the DC response to bacterial and viral infection was investigated in vitro using LPS and Poly I:C as models of infection. CD14{sup +} monocytes, isolated from human peripheral blood, were cultured in GM-CSF- and IL-4-supplemented medium to generate immature DCs. Cultures were incubated with curcumin, stimulated with LPS or Poly I:C and functional assays were performed. Curcumin prevents DCs from responding to immunostimulants and inducing CD4{sup +} T cell proliferation by blocking maturation marker, cytokine and chemokine expression and reducing both migration and endocytosis. These data suggest a therapeutic role for curcumin as an immune suppressant.
Authors:
 [1] ;  [2] ;  [3] ;  [4]
  1. Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612 (United States)
  2. College of Nursing, University of South Florida, Tampa, FL 33612 (United States)
  3. Division of Allergy and Immunology, Joy McCann Culverhouse Airway Disease and Nanomedicine Research Center, Department of Internal Medicine, University of South Florida and VA Hospital Medical Center, MDC 19, 12901 Bruce B. Downs Blvd., Tampa, FL 33612 (United States)
  4. Division of Allergy and Immunology, Joy McCann Culverhouse Airway Disease and Nanomedicine Research Center, Department of Internal Medicine, University of South Florida and VA Hospital Medical Center, MDC 19, 12901 Bruce B. Downs Blvd., Tampa, FL 33612 (United States), E-mail: smohapat@health.usf.edu
Publication Date:
OSTI Identifier:
21143878
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 374; Journal Issue: 3; Other Information: DOI: 10.1016/j.bbrc.2008.07.051; PII: S0006-291X(08)01323-5; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CELL PROLIFERATION; CURCUMIN; DENDRITES; IMMUNOSUPPRESSION; IN VITRO; INFLAMMATION; MONOCYTES