PPAR{alpha} gene expression is up-regulated by LXR and PXR activators in the small intestine

Journal Article · Fri Jul 11 00:00:00 EDT 2008 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2008.04.100· OSTI ID:21143750

Inoue, Jun ^[1]; Satoh, Shin-ichi; Kita, Mariko ^[1]; Nakahara, Mayuko ^[1]; Hachimura, Satoshi ^[1]; Miyata, Masaaki ^[2]; Nishimaki-Mogami, Tomoko ^[3]; Sato, Ryuichiro ^[1]

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1. Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657 (Japan)
2. Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University (Japan)
3. Division of Cell Signaling, National Institute of Health Sciences (Japan)

LXR, PXR, and PPAR{alpha} are members of a nuclear receptor family which regulate the expression of genes involved in lipid metabolism. Here, we show the administration of T0901317 stimulates PPAR{alpha} gene expression in the small intestine but not in the liver of both normal and FXR-null mice. The administration of LXR specific ligand GW3965, or PXR specific ligand PCN has the same effect, indicating that ligand-dependent activation of LXR and PXR, but not FXR, is responsible for the increased gene expression of PPAR{alpha} in the mouse small intestine.

• OSTI ID: 21143750
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 371, Issue 4; Other Information: DOI: 10.1016/j.bbrc.2008.04.100; PII: S0006-291X(08)00786-9; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
GENES
LIGANDS
LIPIDS
LIVER
METABOLISM
MICE
RECEPTORS
SMALL INTESTINE