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Title: The PPAR{gamma} coding region and its role in visceral obesity

Abstract

Peroxisome proliferator-activated receptor gamma (PPAR{gamma}) is a ligand activated transcription factor, plays many essential roles of biological function in higher organisms. The PPAR{gamma} is mainly expressed in adipose tissue. It regulates the transcriptional activity of genes by binding with other transcription factor. The PPAR{gamma} coding region has been found to be closest to that of monkey in ours and other research groups. Thus, monkey is a more suitable animal model for future PPAR{gamma} studying, although mice and rat are frequently being used. The PPAR{gamma} is involved in regulating alterations of adipose tissue masses result from changes in mature adipocyte size and/or number through a complex interplay process called adipogenesis. However, the role of PPAR{gamma} in negatively regulating the process of adipogenesis remains unclear. This review may help we investigate the differential expression of key transcription factor in adipose tissue in response to visceral obesity-induced diet in vivo. The study may also provide valuable information to define a more appropriate physiological condition in adipogenesis which may help to prevent diseases cause by negative regulation of the transcription factors in adipose tissue.

Authors:
 [1];  [1];  [1]
  1. School of Biological Sciences, Universiti Sains Malaysia (USM), 11800 Penang (Malaysia)
Publication Date:
OSTI Identifier:
21143728
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 371; Journal Issue: 2; Other Information: DOI: 10.1016/j.bbrc.2008.04.013; PII: S0006-291X(08)00686-4; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ADIPOSE TISSUE; BIOLOGICAL FUNCTIONS; DIET; GENES; IN VIVO; LIGANDS; METABOLIC DISEASES; MICE; MONKEYS; RATS; RECEPTORS; REVIEWS; TRANSCRIPTION FACTORS

Citation Formats

Boon Yin, Khoo, Institute for Research in Molecular Medicine, Najimudin, Nazalan, Muhammad, Tengku Sifzizul Tengku, Malaysian Institute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Universiti Sains Malaysia, 11800 Penang, and Department of Biological Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu. The PPAR{gamma} coding region and its role in visceral obesity. United States: N. p., 2008. Web. doi:10.1016/j.bbrc.2008.04.013.
Boon Yin, Khoo, Institute for Research in Molecular Medicine, Najimudin, Nazalan, Muhammad, Tengku Sifzizul Tengku, Malaysian Institute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Universiti Sains Malaysia, 11800 Penang, & Department of Biological Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu. The PPAR{gamma} coding region and its role in visceral obesity. United States. https://doi.org/10.1016/j.bbrc.2008.04.013
Boon Yin, Khoo, Institute for Research in Molecular Medicine, Najimudin, Nazalan, Muhammad, Tengku Sifzizul Tengku, Malaysian Institute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Universiti Sains Malaysia, 11800 Penang, and Department of Biological Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu. 2008. "The PPAR{gamma} coding region and its role in visceral obesity". United States. https://doi.org/10.1016/j.bbrc.2008.04.013.
@article{osti_21143728,
title = {The PPAR{gamma} coding region and its role in visceral obesity},
author = {Boon Yin, Khoo and Institute for Research in Molecular Medicine and Najimudin, Nazalan and Muhammad, Tengku Sifzizul Tengku and Malaysian Institute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation, Universiti Sains Malaysia, 11800 Penang and Department of Biological Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu},
abstractNote = {Peroxisome proliferator-activated receptor gamma (PPAR{gamma}) is a ligand activated transcription factor, plays many essential roles of biological function in higher organisms. The PPAR{gamma} is mainly expressed in adipose tissue. It regulates the transcriptional activity of genes by binding with other transcription factor. The PPAR{gamma} coding region has been found to be closest to that of monkey in ours and other research groups. Thus, monkey is a more suitable animal model for future PPAR{gamma} studying, although mice and rat are frequently being used. The PPAR{gamma} is involved in regulating alterations of adipose tissue masses result from changes in mature adipocyte size and/or number through a complex interplay process called adipogenesis. However, the role of PPAR{gamma} in negatively regulating the process of adipogenesis remains unclear. This review may help we investigate the differential expression of key transcription factor in adipose tissue in response to visceral obesity-induced diet in vivo. The study may also provide valuable information to define a more appropriate physiological condition in adipogenesis which may help to prevent diseases cause by negative regulation of the transcription factors in adipose tissue.},
doi = {10.1016/j.bbrc.2008.04.013},
url = {https://www.osti.gov/biblio/21143728}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 2,
volume = 371,
place = {United States},
year = {Fri Jun 27 00:00:00 EDT 2008},
month = {Fri Jun 27 00:00:00 EDT 2008}
}