Mycoplasma fermentans glycolipid-antigen as a pathogen of rheumatoid arthritis
- Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-ku, Kawaramachi-Hirokoji Kamigyo-ku, Kyoto-shi, Kyoto 602-0841 (Japan)
- Laboratory for Electron Microscopy, Tokyo Medical and Dental University, 5-45, Yushima 1-chome, Bunkyo-ku, Tokyo 113-8519 (Japan)
- Arthiritis and Rheumatism Branch, Department of Internal Medicine, Hyogo Medical College of Medicine, 1-1, Nishinomiya, Mukogawa-cho, Hyogo 663-8501 (Japan)
- Department of Orthopedics, Kyoto Prefectural University of Medicine, 465 Kajii-ku, Kawaramachi-Hirokoji Kamigyo-ku, Kyoto, Kyoto 602-0841 (Japan)
- Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3-18-8, Ueda, Morioka, Iwate 020-8550 (Japan)
- Department of Rheumatology and Internal medicine, OUR LADY OF SNOW Medical Juridical Corporation ST. MARY'S HOSPITAL, 422 Tsubukuhon-machi Kurume City, Fukuoka 830-8543 (Japan)
- Department of Research and Developments, M Bio Technology Inc., Koto-ku, TIME 24 Building 10F, Aomi 2-45, Koto-ku, Tokyo 135-8073 (Japan)
Mycoplasma fermentans has been suspected as one of the causative pathogenic microorganisms of rheumatoid arthritis (RA) however, the pathogenic mechanism is still unclear. We, previously, reported that glycolipid-antigens (GGPL-I and III) are the major antigens of M. fermentans. Monoclonal antibody against the GGPL-III could detect the existence of the GGPL-III antigens in synovial tissues from RA patients. GGPL-III antigens were detected in 38.1% (32/84) of RA patient's tissues, but not in osteoarthritis (OA) and normal synovial tissues. Immunoelectron microscopy revealed that a part of GGPL-III antigens are located at endoplasmic reticulum. GGPL-III significantly induced TNF-{alpha} and IL-6 production from peripheral blood mononulear cells, and also proliferation of synovial fibroblasts. Further study is necessary to prove that M. fermentans is a causative microorganism of RA; however, the new mechanisms of disease pathogenesis provides hope for the development of effective and safe immunotherapeutic strategies based on the lipid-antigen, GGPL-III, in the near future.
- OSTI ID:
- 21143651
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 369, Issue 2; Other Information: DOI: 10.1016/j.bbrc.2008.02.079; PII: S0006-291X(08)00312-4; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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