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Title: Carbon Ion Radiation Therapy for Primary Renal Cell Carcinoma: Initial Clinical Experience

Abstract

Purpose: Renal cell carcinoma (RCC) is known as a radioresistant tumor, and there are few reports on radiotherapy for primary RCC. We evaluated the efficacy of carbon ion radiotherapy (CIRT) for patients with RCC. Methods and Materials: Data for patients with RCC who received CIRT were analyzed. A median total dose of 72 GyE (gray equivalents) in 16 fractions was administered without any additional treatment. Clinical stage was determined based on TNM classification by the International Union Against Cancer (UICC). Local recurrence was defined as definite tumor regrowth after treatment. Results: Data for 10 patients were included in the analyses, including 7 patients with Stage I and 3 patients with Stage IV (T4NxM0 or TxN2M0) disease. The median maximum diameter of the tumor was 43 mm (24-120 mm). The median follow-up for surviving patients was 57.5 months (9-111 months). The 5-year local control rate, progression-free survival rate, cause-specific survival rate, and overall survival rates were 100%, 100%, 100%, and 74%, respectively. Interestingly, treated tumors showed very slow shrinkage, and the tumor in 1 case has been shrinking for 9 years. One patient with muscular invasion (T4 tumor) developed Grade 4 skin toxicity, but no other toxicity greater than Grade 2more » was observed. Conclusions: This is one of the few reports on curative radiotherapy for primary RCC. The response of the tumor to treatment was uncommon. However despite inclusion of T4 and massive tumors, favorable local controllability has been shown. The results indicate the possibility of radical CIRT, as well as surgery, for RCC.« less

Authors:
 [1]; ; ; ; ;  [1];  [2];  [3]; ;  [4];  [1]
  1. Research Center for Charged Particle Therapy, National Institute of Radiological Sciences (NIRS), Chiba (Japan)
  2. Department of Pathology, Narita Red Cross Hospital, Chiba (Japan)
  3. Department of Urology, National Hospital Organization Chiba-East Hospital, Chiba (Japan)
  4. Department of Radiation Oncology, Yamagata University Hospital, Yamagata (Japan)
Publication Date:
OSTI Identifier:
21128216
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 72; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2008.01.043; PII: S0360-3016(08)00193-4; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARBON IONS; CARCINOMAS; KIDNEYS; PATIENTS; RADIOTHERAPY; SKIN; SURGERY; TOXICITY

Citation Formats

Nomiya, Takuma, Tsuji, Hiroshi, Hirasawa, Naoki, Kato, Hiroyuki, Kamada, Tadashi, Mizoe, Junetsu, Kishi, Hirohisa, Kamura, Koichi, Wada, Hitoshi, Nemoto, Kenji, and Tsujii, Hirohiko. Carbon Ion Radiation Therapy for Primary Renal Cell Carcinoma: Initial Clinical Experience. United States: N. p., 2008. Web. doi:10.1016/j.ijrobp.2008.01.043.
Nomiya, Takuma, Tsuji, Hiroshi, Hirasawa, Naoki, Kato, Hiroyuki, Kamada, Tadashi, Mizoe, Junetsu, Kishi, Hirohisa, Kamura, Koichi, Wada, Hitoshi, Nemoto, Kenji, & Tsujii, Hirohiko. Carbon Ion Radiation Therapy for Primary Renal Cell Carcinoma: Initial Clinical Experience. United States. https://doi.org/10.1016/j.ijrobp.2008.01.043
Nomiya, Takuma, Tsuji, Hiroshi, Hirasawa, Naoki, Kato, Hiroyuki, Kamada, Tadashi, Mizoe, Junetsu, Kishi, Hirohisa, Kamura, Koichi, Wada, Hitoshi, Nemoto, Kenji, and Tsujii, Hirohiko. 2008. "Carbon Ion Radiation Therapy for Primary Renal Cell Carcinoma: Initial Clinical Experience". United States. https://doi.org/10.1016/j.ijrobp.2008.01.043.
@article{osti_21128216,
title = {Carbon Ion Radiation Therapy for Primary Renal Cell Carcinoma: Initial Clinical Experience},
author = {Nomiya, Takuma and Tsuji, Hiroshi and Hirasawa, Naoki and Kato, Hiroyuki and Kamada, Tadashi and Mizoe, Junetsu and Kishi, Hirohisa and Kamura, Koichi and Wada, Hitoshi and Nemoto, Kenji and Tsujii, Hirohiko},
abstractNote = {Purpose: Renal cell carcinoma (RCC) is known as a radioresistant tumor, and there are few reports on radiotherapy for primary RCC. We evaluated the efficacy of carbon ion radiotherapy (CIRT) for patients with RCC. Methods and Materials: Data for patients with RCC who received CIRT were analyzed. A median total dose of 72 GyE (gray equivalents) in 16 fractions was administered without any additional treatment. Clinical stage was determined based on TNM classification by the International Union Against Cancer (UICC). Local recurrence was defined as definite tumor regrowth after treatment. Results: Data for 10 patients were included in the analyses, including 7 patients with Stage I and 3 patients with Stage IV (T4NxM0 or TxN2M0) disease. The median maximum diameter of the tumor was 43 mm (24-120 mm). The median follow-up for surviving patients was 57.5 months (9-111 months). The 5-year local control rate, progression-free survival rate, cause-specific survival rate, and overall survival rates were 100%, 100%, 100%, and 74%, respectively. Interestingly, treated tumors showed very slow shrinkage, and the tumor in 1 case has been shrinking for 9 years. One patient with muscular invasion (T4 tumor) developed Grade 4 skin toxicity, but no other toxicity greater than Grade 2 was observed. Conclusions: This is one of the few reports on curative radiotherapy for primary RCC. The response of the tumor to treatment was uncommon. However despite inclusion of T4 and massive tumors, favorable local controllability has been shown. The results indicate the possibility of radical CIRT, as well as surgery, for RCC.},
doi = {10.1016/j.ijrobp.2008.01.043},
url = {https://www.osti.gov/biblio/21128216}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 72,
place = {United States},
year = {Sat Nov 01 00:00:00 EDT 2008},
month = {Sat Nov 01 00:00:00 EDT 2008}
}