Aging by epigenetics-A consequence of chromatin damage?
Journal Article
·
· Experimental Cell Research
- Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 (United States)
Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.
- OSTI ID:
- 21128185
- Journal Information:
- Experimental Cell Research, Vol. 314, Issue 9; Other Information: DOI: 10.1016/j.yexcr.2008.02.023; PII: S0014-4827(08)00110-9; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0014-4827
- Country of Publication:
- United States
- Language:
- English
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