Influence of Radiotherapy Treatment Concept on the Outcome of Patients With Localized Ependymomas

Journal Article · Tue Jul 15 00:00:00 EDT 2008 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2007.12.036· OSTI ID:21124339

Kelter, Verena; Welzel, Thomas ^[1]; Behnisch, Wolfgang; Kulozik, Andreas E ^[2]; Bischof, Marc; Hof, Holger; Debus, Juergen; Schulz-Ertner, Daniela ^[1]

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1. Neuro-Radiation Oncology Research Group, Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany)
2. Department of Pediatric Hematology and Oncology, University of Heidelberg, Heidelberg (Germany)

Purpose: To assess the outcome of 57 patients with localized ependymomas treated with radiotherapy (RT). Methods and Materials: Fifty-seven patients with localized ependymomas were treated with RT. Histology was myxopapillary ependymoma (n = 4), ependymoma (n = 23), and anaplastic ependymoma (n = 30). In 16 patients, irradiation of the craniospinal axis (CSI) was performed with a median dose of 20 Gy. Forty-one patients were treated with local RT, with a local dose of 45 Gy to the posterior fossa, including a boost to the tumor bed of 9 Gy. In 19 patients, the tumor bed was irradiated with a median dose of 54 Gy. Results: Overall survival after primary diagnosis was 83% and 71% at 3 and 5 years. Five-year overall survival was 80% in low-grade and 79% in high-grade tumors. Survival from RT was 79% at 3 and 64% at 5 years. We could not show a significant difference in overall survival between CSI and local RT only. Freedom of local failure was 67% at 5 years in patients treated with CSI and 60% at 5 years after local RT. A rate of 83% for distant failure-free survival could be observed in the CSI group as opposed to 93% in the group receiving local RT only. Conclusion: Local RT in patients with localized tumors is equieffective to CSI. The radiation oncologist must keep in mind that patients with localized ependymomas benefit from local doses {>=}45 Gy.

• OSTI ID: 21124339
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 71, Issue 4; Other Information: DOI: 10.1016/j.ijrobp.2007.12.036; PII: S0360-3016(07)04777-3; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DIAGNOSIS
FAILURES
HISTOLOGY
IRRADIATION
MEDICAL PERSONNEL
NEOPLASMS
PATIENTS
RADIATION DOSES
RADIOTHERAPY
TOXICITY