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Title: The Road to Bioabsorbable Stents: Reaching Clinical Reality?

This article provides an overview of the evolution of revascularization devices since Gruentzig's initial introduction of balloon angioplasty in 1977. In-stent restenosis (ISR) is the major shortcoming of conventional (permanent-implant) stent therapy; even with the innovation and promising benefits of drug-eluting stents, management of ISR is very difficult. ISR is mainly caused by the interaction between the blood and the stent surface and a permanent mechanical irritation of the vascular tissue. Thus stenting technology has moved toward the development of temporary implants composed of biocompatible materials which mechanically support the vessel during the period of high risk for recoil and then completely biodegrade in the long term. Preclinical and first clinical experiences with bioabsorbable magnesium stents are discussed.
Authors:
 [1] ;  [2] ;  [3]
  1. Kantonsspital Luzern, Division of Cardiology (Switzerland), E-mail: Paul.Erne@KSL.CH
  2. Biotronik GmbH and Co. KG (Germany)
  3. Basel University Hospital, Department of Research (Switzerland)
Publication Date:
OSTI Identifier:
21091292
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 29; Journal Issue: 1; Other Information: DOI: 10.1007/s00270-004-0341-9; Copyright (c) 2006 Springer Science+Business Media, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD; DRUGS; EQUIPMENT; IMPLANTS; MAGNESIUM; THERAPY; VASCULAR DISEASES