A New Method of Selective, Rapid Cooling of the Brain: An Experimental Study
- Lund University, Lund University Hospital, Divisions of Thorasic Surgery (Sweden)
- Lund University, Lund University Hospital, Divisions of Anesthesiology (Sweden)
- Lund University, Lund University Hospital, Divisions of Radiology (Sweden)
- Lund University, Lund University Hospital, Divisions of Experimental Brain Research, Department of Clinical Sciences (Sweden)
Purpose. To determine whether retrograde perfusion of cooled blood into one internal jugular vein (IJV) in the pig can selectively reduce the brain temperature without affecting the core body temperature (CBT). Methods. In 7 domestic pigs, the left IJV was catheterized on one side and a catheter placed with the tip immediately below the rete mirabile. Thermistors were placed in both brain hemispheres and the brain temperature continuously registered. Thermistors placed in the rectum registered the CBT. From a catheter in the right femoral vein blood was aspirated with the aid of a roller pump, passed through a cooling device, and infused into the catheter in the left IJV at an initial rate of 200 ml/min. Results. Immediately after the start of the infusion of cooled blood (13.8 deg. C) into the IJV, the right brain temperature started to drop from its initial 37.9 deg. C and reached 32 deg. C within 5 min. By increasing the temperature of the perfusate a further drop in the brain temperature was avoided and the brain temperature could be kept around 32 deg. C during the experiment. In 4 of the animals a heating blanket was sufficient to compensate for the slight drop in CBT during the cooling period. Conclusions. We conclude that brain temperature can be reduced in the pig by retrograde perfusion of the internal jugular vein with cooled blood and that the core body temperature can be maintained with the aid of a heating blanket.
- OSTI ID:
- 21091266
- Journal Information:
- Cardiovascular and Interventional Radiology, Vol. 29, Issue 2; Other Information: DOI: 10.1007/s00270-004-0271-6; Copyright (c) 2006 Springer Science+Business Media, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
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