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Title: Experiences in US-Guided Percutaneous Radiofrequency Ablation of 44 Renal Tumors in 31 Patients: Analysis of Predictors for Complications and Technical Success

Abstract

Purpose. Preliminary clinical studies have shown the feasibility, safety, and efficacy of radiofrequency thermal ablation (RFA) of renal tumors, but only a few have analyzed the prognostic factors for technical success and there are no long-term results. Our objective was to statistically evaluate our mid-term results of percutaneous US-guided RFA in order to define predictors for complications and technical success. Methods. We selected for treatment 44 tumors in 31 patients (24 with renal cell carcinoma, 7 with hereditary tumors, 15 with a solitary kidney), up to 5 cm in diameter. Results. Eight adverse events occurred; 3 (6.8%) were major complications, successfully treated with interventional radiology procedures in 2 cases. Exophytic extension of the tumor was protective against complications (p 0.040). Technical success was obtained in 38 lesions after one RFA session and in 39 (89%) after one more session, when possible. At the end of treatment, central extension was the only negative predictor for technical success (p = 0.007), while neither size >3 cm (p = 0.091) nor other prognostic factors were statistically significant. Conclusion. US-guided percutaneous RFA can be proposed for non-central renal tumors up to 5 cm, also in patients without surgical contraindications, thanks to a low incidencemore » of complications and a high success rate. Randomized controlled trials versus surgery are now needed to investigate long-term comparative results.« less

Authors:
; ;  [1];  [2]; ;  [1];  [3];  [4];  [1]
  1. University of Turin, Institute of Diagnostic and Interventional Radiology (Italy)
  2. University of Turin, Unit of Cancer Epidemiology (Italy)
  3. San Giovanni Battista Hospital, Unit of Urology (Italy)
  4. University of Turin, Institute of Urology (Italy)
Publication Date:
OSTI Identifier:
21091134
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 29; Journal Issue: 5; Other Information: DOI: 10.1007/s00270-005-0261-3; Copyright (c) 2006 Springer Science+Business Media, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; BIOMEDICAL RADIOGRAPHY; CARCINOMAS; KIDNEYS; PATIENTS; RADIOWAVE RADIATION; SURGERY

Citation Formats

Veltri, Andrea, Calvo, Amedeo, Tosetti, Irene, Pagano, Eva, Genovesio, Andrea, Virzi, Valentina, Ferrando, Ugo, Fontana, Dario, and Gandini, Giovanni. Experiences in US-Guided Percutaneous Radiofrequency Ablation of 44 Renal Tumors in 31 Patients: Analysis of Predictors for Complications and Technical Success. United States: N. p., 2006. Web. doi:10.1007/S00270-005-0261-3.
Veltri, Andrea, Calvo, Amedeo, Tosetti, Irene, Pagano, Eva, Genovesio, Andrea, Virzi, Valentina, Ferrando, Ugo, Fontana, Dario, & Gandini, Giovanni. Experiences in US-Guided Percutaneous Radiofrequency Ablation of 44 Renal Tumors in 31 Patients: Analysis of Predictors for Complications and Technical Success. United States. https://doi.org/10.1007/S00270-005-0261-3
Veltri, Andrea, Calvo, Amedeo, Tosetti, Irene, Pagano, Eva, Genovesio, Andrea, Virzi, Valentina, Ferrando, Ugo, Fontana, Dario, and Gandini, Giovanni. 2006. "Experiences in US-Guided Percutaneous Radiofrequency Ablation of 44 Renal Tumors in 31 Patients: Analysis of Predictors for Complications and Technical Success". United States. https://doi.org/10.1007/S00270-005-0261-3.
@article{osti_21091134,
title = {Experiences in US-Guided Percutaneous Radiofrequency Ablation of 44 Renal Tumors in 31 Patients: Analysis of Predictors for Complications and Technical Success},
author = {Veltri, Andrea and Calvo, Amedeo and Tosetti, Irene and Pagano, Eva and Genovesio, Andrea and Virzi, Valentina and Ferrando, Ugo and Fontana, Dario and Gandini, Giovanni},
abstractNote = {Purpose. Preliminary clinical studies have shown the feasibility, safety, and efficacy of radiofrequency thermal ablation (RFA) of renal tumors, but only a few have analyzed the prognostic factors for technical success and there are no long-term results. Our objective was to statistically evaluate our mid-term results of percutaneous US-guided RFA in order to define predictors for complications and technical success. Methods. We selected for treatment 44 tumors in 31 patients (24 with renal cell carcinoma, 7 with hereditary tumors, 15 with a solitary kidney), up to 5 cm in diameter. Results. Eight adverse events occurred; 3 (6.8%) were major complications, successfully treated with interventional radiology procedures in 2 cases. Exophytic extension of the tumor was protective against complications (p 0.040). Technical success was obtained in 38 lesions after one RFA session and in 39 (89%) after one more session, when possible. At the end of treatment, central extension was the only negative predictor for technical success (p = 0.007), while neither size >3 cm (p = 0.091) nor other prognostic factors were statistically significant. Conclusion. US-guided percutaneous RFA can be proposed for non-central renal tumors up to 5 cm, also in patients without surgical contraindications, thanks to a low incidence of complications and a high success rate. Randomized controlled trials versus surgery are now needed to investigate long-term comparative results.},
doi = {10.1007/S00270-005-0261-3},
url = {https://www.osti.gov/biblio/21091134}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 5,
volume = 29,
place = {United States},
year = {Sun Oct 15 00:00:00 EDT 2006},
month = {Sun Oct 15 00:00:00 EDT 2006}
}