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Title: Volume Changes of Experimental Carotid Sidewall Aneurysms Due to Embolization with Liquid Embolic Agents: A Multidetector CT Angiography Study

Iodine-containing polyvinyl alcohol polymer (I-PVAL) is a novel precipitating liquid embolic that allows for artifact-free evaluation of CT angiography (CTA). As accurate aneurysm volumetry can be performed with multidetector CTA, we determined volumes of experimental aneurysms before, immediately after, and 4 weeks after embolization of 14 porcine experimental carotid sidewall aneurysms with this liquid embolic. An automated three-dimensional software measurement tool was used for volumetric analysis of volume-rendering CTA data. Furthermore, intra-aneurysmal pressure changes during liquid embolization were measured in four silicone aneurysms and potential polymer volume changes within 4 weeks were assessed in vitro. Liquid embolic injection was performed during temporary balloon occlusion of the aneurysm neck, resulting in a mean occlusion rate of 98.3%. Aneurysms enlarged significantly during embolization by 61.1 {+-} 28.9%, whereas a significant shrinkage of 5.6 {+-} 2.7% was observed within the follow-up period. Histologic analysis revealed an inflammatory foreign body reaction with partial polymer degradation. In silicone aneurysm models, intra-aneurysmal pressure remained unchanged during liquid embolic injection, whereas balloon inflation resulted in a mean pressure increase of 31.2 {+-} 0.7%. No polymer shrinkage was observed in vitro. The aneurysm enlargement noted was presumably due to pressure elevation after balloon inflation, which resulted in dilatationmore » of the weak venous wall of the newly constructed aneurysm-another shortcoming of this experimental aneurysm model. The volume decrease after 4 weeks expressed partial polymer degradation.« less
Authors:
 [1] ;  [2] ;  [3] ; ;  [4] ;  [5] ;  [6] ;  [3] ;  [4]
  1. Charite, Campus Virchow Clinic, Department of Radiology (Germany), E-mail: oliver.dudeck@charite.de
  2. Charite, Campus Virchow Clinic, Department of Neuropathology (Germany)
  3. University of Geneva, School of Pharmacy (Switzerland)
  4. Charite, Campus Virchow Clinic, Department of Radiology (Germany)
  5. Albert-Ludwigs-University of Freiburg, Department of Cardiovascular Surgery (Germany)
  6. University Hospital of Geneva, Neuroradiology Section (Switzerland)
Publication Date:
OSTI Identifier:
21091101
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 29; Journal Issue: 6; Other Information: DOI: 10.1007/s00270-005-2361-5; Copyright (c) 2006 Springer Science+Business Media, Inc.; www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; BLOOD VESSELS; COMPUTERIZED TOMOGRAPHY; IN VITRO; INFLAMMATION; INJECTION; IODINE; PVA; SILICONES; VOLUMETRIC ANALYSIS