Combined application of neutron and synchrotron radiation for investigation of the influence of dimethyl sulfoxide on the structure and properties of the dipalmitoylphosphatidylcholine membrane

Journal Article · Tue May 15 00:00:00 EDT 2007 · Crystallography Reports

DOI:https://doi.org/10.1134/S1063774507030352· OSTI ID:21090901

Kiselev, M. A. ^[1]

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1. Joint Institute for Nuclear Research (Russian Federation), E-mail: [e-mail]

The influence of dimethyl sulfoxide (DMSO) on the structure and properties of the dipalmitoylphosphatidylcholine membrane was studied at positive temperatures by a combination of X-ray diffraction and small-angle neutron scattering. Penetration of DMSO molecules into the lipid membrane was found to depend on the mole fraction of DMSO in an aqueous solution, X{sub DMSO}. At X{sub DMSO} > 0.08 the SO group penetrates into the bilayer polar region, thus resulting in structural alterations. At X{sub DMSO} > 0.2 defects in the membrane surface are developed.

• OSTI ID: 21090901
• Journal Information: Crystallography Reports, Vol. 52, Issue 3; Other Information: DOI: 10.1134/S1063774507030352; Copyright (c) 2007 Nauka/Interperiodica; Article Copyright (c) 2007 Pleiades Publishing, Inc; Country of input: International Atomic Energy Agency (IAEA); ISSN 1063-7745
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
AQUEOUS SOLUTIONS
DMSO
MEMBRANES
NEUTRON DIFFRACTION
PHOSPHOLIPIDS
SMALL ANGLE SCATTERING
SYNCHROTRON RADIATION
X-RAY DIFFRACTION