Experimental Study on Transarterial Administration of GRGDSP Combined with Transarterial Chemoembolization in Rats with Hepatic Carcinoma
Abstract
Purpose. To evaluate the effects of transarterial administration of an integrin antagonist, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro), combined with transarterial chemoembolization (TACE) to treat hepatic carcinoma in rats. Methods. Walker-256 tumor was implanted beneath the liver capsule in 26 Wistar rats. Animal subjects were assigned to groups based on which treatment was injected into the hepatic artery: group A, GRGDSP + TACE; group B, TACE alone; and group C, normal saline. Magnetic resonance imaging (MRI), tumor pathology, and immunohistochemistry were performed to assess each treatment. Results. The ratios of the post-treatment to pretreatment tumor volumes (V2/V1) in groups A, B, and C were 4.42 {+-} 0.48, 6.98 {+-} 1.09, and 13.00 {+-} 1.68, respectively. The metastatic potential of the tumors was assessed by tumor cell nest counts, which were 5.00 {+-} 1.25, 6.63 {+-} 1.60, and 7.22 {+-} 1.92 in groups A, B, and C, respectively. Microvessel density (MVD) was quantified by measuring von Willebrand factor density values, which were 0.18 {+-} 0.02, 0.22 {+-} 0.02, and 0.23 {+-} 0.02 in groups A, B, and C, respectively. Conclusions. Transarterial infusion of GRGDSP combined with TACE noticeably inhibited the growth of hepatic carcinoma and intrahepatic metastases in rats.
- Authors:
-
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Department of Radiology (China)
- Publication Date:
- OSTI Identifier:
- 21090631
- Resource Type:
- Journal Article
- Journal Name:
- Cardiovascular and Interventional Radiology
- Additional Journal Information:
- Journal Volume: 31; Journal Issue: 2; Other Information: DOI: 10.1007/s00270-007-9233-0; Copyright (c) 2008 Springer Science+Business Media, LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; CARCINOMAS; INFUSION; LIVER; METASTASES; NMR IMAGING; PATHOLOGY; RATS; TUMOR CELLS
Citation Formats
Qian Jun, E-mail: qianjun_hcc@yahoo.com, Jun, Yin, Huimin, Liang, Yong, Wang, and Gansheng, Feng. Experimental Study on Transarterial Administration of GRGDSP Combined with Transarterial Chemoembolization in Rats with Hepatic Carcinoma. United States: N. p., 2008.
Web. doi:10.1007/S00270-007-9233-0.
Qian Jun, E-mail: qianjun_hcc@yahoo.com, Jun, Yin, Huimin, Liang, Yong, Wang, & Gansheng, Feng. Experimental Study on Transarterial Administration of GRGDSP Combined with Transarterial Chemoembolization in Rats with Hepatic Carcinoma. United States. https://doi.org/10.1007/S00270-007-9233-0
Qian Jun, E-mail: qianjun_hcc@yahoo.com, Jun, Yin, Huimin, Liang, Yong, Wang, and Gansheng, Feng. 2008.
"Experimental Study on Transarterial Administration of GRGDSP Combined with Transarterial Chemoembolization in Rats with Hepatic Carcinoma". United States. https://doi.org/10.1007/S00270-007-9233-0.
@article{osti_21090631,
title = {Experimental Study on Transarterial Administration of GRGDSP Combined with Transarterial Chemoembolization in Rats with Hepatic Carcinoma},
author = {Qian Jun, E-mail: qianjun_hcc@yahoo.com and Jun, Yin and Huimin, Liang and Yong, Wang and Gansheng, Feng},
abstractNote = {Purpose. To evaluate the effects of transarterial administration of an integrin antagonist, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro), combined with transarterial chemoembolization (TACE) to treat hepatic carcinoma in rats. Methods. Walker-256 tumor was implanted beneath the liver capsule in 26 Wistar rats. Animal subjects were assigned to groups based on which treatment was injected into the hepatic artery: group A, GRGDSP + TACE; group B, TACE alone; and group C, normal saline. Magnetic resonance imaging (MRI), tumor pathology, and immunohistochemistry were performed to assess each treatment. Results. The ratios of the post-treatment to pretreatment tumor volumes (V2/V1) in groups A, B, and C were 4.42 {+-} 0.48, 6.98 {+-} 1.09, and 13.00 {+-} 1.68, respectively. The metastatic potential of the tumors was assessed by tumor cell nest counts, which were 5.00 {+-} 1.25, 6.63 {+-} 1.60, and 7.22 {+-} 1.92 in groups A, B, and C, respectively. Microvessel density (MVD) was quantified by measuring von Willebrand factor density values, which were 0.18 {+-} 0.02, 0.22 {+-} 0.02, and 0.23 {+-} 0.02 in groups A, B, and C, respectively. Conclusions. Transarterial infusion of GRGDSP combined with TACE noticeably inhibited the growth of hepatic carcinoma and intrahepatic metastases in rats.},
doi = {10.1007/S00270-007-9233-0},
url = {https://www.osti.gov/biblio/21090631},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 2,
volume = 31,
place = {United States},
year = {Sat Mar 15 00:00:00 EDT 2008},
month = {Sat Mar 15 00:00:00 EDT 2008}
}