A Comparison of the Efficacy and Safety of Ioxaglate and Iobitridol in Renal Angioplasty
- Department of Radiology, University Hospital, BP 69, F-63003, Clermont-Ferrand (France)
- Department of Radiology, Rangueil University Hospital, 1 Avenue J. Poulhes, F-31054 Toulouse (France)
- Department of Radiology, University Hospital, 2 Boulevard De Lattre de Tassigny, F-21034 Dijon (France)
- Department of Radiology, La Timone University Hospital, 264 rue St. Pierre, F-13385 Marseille Cedex 5 (France)
- Department of Radiology, E. Herriot University Hospital, Pavillon P, 5 place d'Arsonval, F-69437 Lyon Cedex 03 (France)
- Department of Radiology, University Hospital, F-42055 St. Etienne Cedex 2 (France)
Purpose: To compare ioxaglate and iobitridol for percutaneous transluminal renal angioplasty (PTRA) as regards thromboembolic complications, the quality of diagnosis, and renal and general safety.Methods: One hundred and eighty-nine patients were prospectively studied, 98 of whom received ioxaglate, and 91, iobitridol. Twenty-two were secondarily excluded from the evaluation of thromboembolic complications as they did not undergo PTRA.Results: Two hundred and two PTRAs were performed. The total volumes of contrast medium administered and the procedure durations were the same for each patient. In the ioxaglate group, four dissections (3 stents), one occlusive dissection, and two spasms occurred; in the iobitridol group, there were three dissections (all stented), one occlusive dissection (stented), and two spasms. The final angiograms showed four renal infarctions with ioxaglate (2 of which were in patients who were not anticoagulated), two with iobitridol. No significant difference was seen in the incidence of thromboembolic complications when the PTRA was performed after anticoagulation (n = 150; 3.9% vs 4%, p = 0.78); in the whole population, thromboembolic complications were more frequent in the ioxaglate group but the difference was not significant (5.7% vs 3.7%, p = 0.74). The quality of the diagnosis and the general and renal safety were the same in the two groups.Conclusion: Regarding the clotting phenomenon, we recorded as many thromboembolic complications with ioxaglate as with iobitridol.
- OSTI ID:
- 21083672
- Journal Information:
- Cardiovascular and Interventional Radiology, Vol. 23, Issue 2; Other Information: DOI: 10.1007/s002709910020; Copyright (c) 2000 Springer-Verlag New York Inc; Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
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