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Title: Gene Therapy Techniques for Peripheral Arterial Disease

Abstract

Somatic gene therapy is the introduction of new genetic material into selective somatic cells with resulting therapeutic benefits. Vascular wall and, subsequently, cardiovascular diseases have become an interesting target for gene therapy studies.Arteries are an attractive target for gene therapy since vascular interventions, both open surgical and endovascular, are well suited for minimally invasive, easily monitored gene delivery. Promising therapeutic effects have been obtained in animal models in preventing post-angioplasty restenosis and vein graft thickening, as well as increasing blood flow and collateral development in ischemic limbs.First clinical trials suggest a beneficial effect of vascular endothelial growth factor in achieving therapeutic angiogenesis in chronic limb ischemia and the efficacy of decoy oligonucleotides to prevent infrainguinal vein graft stenosis. However, further studies are mandatory to clarify the safety issues, to develop better gene delivery vectors and delivery catheters, to improve transgene expression, as well as to find the most effective and safe treatment genes.

Authors:
 [1];  [2]
  1. Department of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, FIN-70210 Kuopio (Finland)
  2. Departmentof Surgery, and Gene Therapy Unit, Kuopio University Hospital, Puijonlaaksontie 2, FIN-70210 Kuopio (Finland)
Publication Date:
OSTI Identifier:
21083445
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 25; Journal Issue: 2; Other Information: DOI: 10.1007/s00270-001-0117-4; Copyright (c) 2002 Springer-Verlag New York, Inc; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; BLOOD FLOW; CLINICAL TRIALS; GENE THERAPY; GENES; GRAFTS; GROWTH FACTORS; ISCHEMIA; LIMBS; OLIGONUCLEOTIDES; SOMATIC CELLS; SURGERY; VEINS

Citation Formats

Manninen, Hannu I, and Maekinen, Kimmo. Gene Therapy Techniques for Peripheral Arterial Disease. United States: N. p., 2002. Web. doi:10.1007/S00270-001-0117-4.
Manninen, Hannu I, & Maekinen, Kimmo. Gene Therapy Techniques for Peripheral Arterial Disease. United States. https://doi.org/10.1007/S00270-001-0117-4
Manninen, Hannu I, and Maekinen, Kimmo. 2002. "Gene Therapy Techniques for Peripheral Arterial Disease". United States. https://doi.org/10.1007/S00270-001-0117-4.
@article{osti_21083445,
title = {Gene Therapy Techniques for Peripheral Arterial Disease},
author = {Manninen, Hannu I and Maekinen, Kimmo},
abstractNote = {Somatic gene therapy is the introduction of new genetic material into selective somatic cells with resulting therapeutic benefits. Vascular wall and, subsequently, cardiovascular diseases have become an interesting target for gene therapy studies.Arteries are an attractive target for gene therapy since vascular interventions, both open surgical and endovascular, are well suited for minimally invasive, easily monitored gene delivery. Promising therapeutic effects have been obtained in animal models in preventing post-angioplasty restenosis and vein graft thickening, as well as increasing blood flow and collateral development in ischemic limbs.First clinical trials suggest a beneficial effect of vascular endothelial growth factor in achieving therapeutic angiogenesis in chronic limb ischemia and the efficacy of decoy oligonucleotides to prevent infrainguinal vein graft stenosis. However, further studies are mandatory to clarify the safety issues, to develop better gene delivery vectors and delivery catheters, to improve transgene expression, as well as to find the most effective and safe treatment genes.},
doi = {10.1007/S00270-001-0117-4},
url = {https://www.osti.gov/biblio/21083445}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 2,
volume = 25,
place = {United States},
year = {Fri Mar 15 00:00:00 EST 2002},
month = {Fri Mar 15 00:00:00 EST 2002}
}