Arterial Hepatic Embolization of Unresectable Hepatocellular Carcinoma Using a Cyanoacrylate/Lipiodol Mixture
- Department of Internal Medicine I, Clinical Division of Oncology, University of Vienna Medical School, Waehringer Guertel 18-20, A-1090 Vienna (Austria)
- Department of Internal Medicine IV, Clinical Division of Gastroenterology and Hepatology, University of Vienna Medical School, Waehringer Guertel 18-20, A-1090 Vienna (Austria)
- Department of Radiology, Clinical Division of Interventional Radiology, University of Vienna Medical School, Waehringer Guertel 18-20, A-1090 Vienna (Austria)
Purpose: A survival analysis in 16 patients with unresectable hepatocellular carcinoma (HCC) undergoing transcatheter arterial embolization (TAE) using a combination of lipiodol and N-butyl-2-cyanoacrylate (5 : 1) was performed in a retrospective study. Methods: A combination of lipiodol and N-butyl-2-cyanoacrylate (5 : 1) was used for TAE. All patients had disease compatible with Okuda stages I and II. Results: Twenty-four embolizations were done; five patients had more than one embolization. Median alpha-fetoprotein levels declined from 116 to 48.6 ng/ml. A median of 0.3 ml cyanoacrylate was administered per patient. Median survival was 8.5 months (range 2-49 months). After a median follow-up of 4 years, 12 patients have died (75%). Okuda stage I and II patients had a median survival time of 34.4 and 5.5 months respectively. Few side effects (19%) were seen. Conclusion: We conclude that the TAE procedure used [lipiodol and N-butyl-2-cyanoacrylate (5 : 1)] is safe and produced only few side effects, thus constituting a valuable therapeutic option for patients with Okuda stage I andII HCC.
- OSTI ID:
- 21080410
- Journal Information:
- Cardiovascular and Interventional Radiology, Vol. 21, Issue 3; Other Information: DOI: 10.1007/s002709900247; Copyright (c) 1996 Springer-Verlag New York Inc; Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
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