Simian varicella virus reactivation in cynomolgus monkeys
- Department of Neurology , University of Colorado Health Sciences Center, Denver, CO 80262 (United States)
- Department of Microbiology, Tulane Regional Primate Research Center, Covington, LA 70433 (United States)
- Tulane University Cancer Center, Tulane Health Sciences Center, New Orleans, LA 70112 (United States)
SVV infection of primates closely resembles VZV infection of humans. Like VZV, SVV becomes latent in ganglionic neurons. We used this model to study the effect of immunosuppression on varicella reactivation. Cynomolgus monkeys latently infected with SVV were irradiated and treated with tacrolimus and prednisone. Of four latently infected monkeys that were immunosuppressed and subjected to the stress of transportation and isolation, one developed zoster, and three others developed features of subclinical reactivation. Another non-immunosuppressed latently infected monkey that was subjected to the same stress of travel and isolation showed features of subclinical reactivation. Virus reactivation was confirmed not only by the occurrence of zoster in one monkey, but also by the presence of late SVV RNA in ganglia, and the detection of SVV DNA in non-ganglionic tissue, and SVV antigens in skin, ganglia and lung.
- OSTI ID:
- 21077988
- Journal Information:
- Virology, Vol. 368, Issue 1; Other Information: DOI: 10.1016/j.virol.2007.06.025; PII: S0042-6822(07)00419-9; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0042-6822
- Country of Publication:
- United States
- Language:
- English
Similar Records
Intracellular localization of varicella-zoster virus ORF39 protein and its functional relationship to glycoprotein K
Demonstration of NK cell-mediated lysis of varicella-zoster virus (VZV)-infected cells: characterization of the effector cells