FoxA1 as a lineage-specific oncogene in luminal type breast cancer

Journal Article · Fri Jan 25 00:00:00 EST 2008 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2007.11.064· OSTI ID:21043586

Yamaguchi, Noritaka ^[1]; Ito, Emi ^[2]; Azuma, Sakura ^[3]; Honma, Reiko; Yanagisawa, Yuka ^[2]; Nishikawa, Akira ^[2]; Kawamura, Mika ^[2]; Imai, Jun-ichi ^[2]

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1. Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku-ku, Tokyo 162-0041 (Japan)
2. Department of Clinical Informatics, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 (Japan)
3. Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan)

The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast cancer. We found that FoxA1 is expressed at high levels in all ErbB2-positive cell lines and a subset of ErbB2-negative cell lines. Down-regulation of FoxA1 by RNA interference significantly suppressed proliferation of ErbB2-negative and FoxA1-positive breast cancer cell lines. Down-regulation of FoxA1 also enhanced the toxic effect of Herceptin on ErbB2-positive cell lines through induction of apoptosis. Taken together with previous data that FoxA1 is a marker of luminal cells in mammary gland, our present results suggest that FoxA1 plays an important role as a lineage-specific oncogene in proliferation of cancer cells derived from mammary luminal cells.

• OSTI ID: 21043586
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 365, Issue 4; Other Information: DOI: 10.1016/j.bbrc.2007.11.064; PII: S0006-291X(07)02430-8; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
APOPTOSIS
CARCINOMAS
GENE REGULATION
MAMMARY GLANDS
ONCOGENES
PHENOBARBITAL
RNA
TOXICITY
TRANSCRIPTION FACTORS