Search of type 2 diabetes susceptibility gene on chromosome 20q

Takeuchi, F; Yanai, K; Inomata, H; Kuzuya, N; Kajio, H; Honjo, S; Takeda, N; Kaburagi, Y; Yasuda, K; Shirasawa, S; Sasazuki, T; Kato, N

doi:10.1016/j.bbrc.2007.04.063

Title: Search of type 2 diabetes susceptibility gene on chromosome 20q

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Abstract

Significant evidence of linkage to type 2 diabetes (T2D) has been shown in a relatively broad region on chromosome 20q, where the hepatocyte nuclear factor-4{alpha} (HNF4A) has been noted as a positional candidate. To systematically evaluate genetic susceptibility to T2D in the relevant region, we examined the disease association by using 1145 SNPs in two-step screening in the Japanese population. The marker screening enabled us to identify significant disease association in the lipopolysaccharide binding protein (LBP) but not in the HNF4A locus. In a 17.7-Mb interval screened, the strongest association was identified for a SNP, rs2232592, located in the intron of LBP, with an estimated odds ratio of 1.73 (95% CI 1.30-2.31) (P 0.0002) in the whole study panel involving 675 case and 474 control subjects. Our data suggest that the LBP gene may confer genetic susceptibility to T2D and this warrants further replication study.

Authors:

Takeuchi, F ^[1]; Yanai, K ^[2]; Inomata, H ^[2]; Kuzuya, N ^[3]; Kajio, H ^[3]; Honjo, S ^[3]; Takeda, N ^[4]; Kaburagi, Y ^[5]; Yasuda, K ^[5]; Shirasawa, S ^[6]; Sasazuki, T ^[7]; Kato, N ^[2]

Department of Medical Ecology and Informatics, Research Institute, International Medical Center of Japan, Tokyo (Japan)
Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655 (Japan)
Division of Metabolic Diseases, The Hospital, International Medical Center of Japan, Tokyo (Japan)
Division of Ophthalmology, The Hospital, International Medical Center of Japan, Tokyo (Japan)
Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo (Japan)
Department of Pathology, Research Institute, International Medical Center of Japan, Tokyo (Japan)
President, International Medical Center of Japan, Tokyo (Japan)

Publication Date:: Fri Jun 15 00:00:00 EDT 2007

OSTI Identifier:: 20991390

Resource Type:: Journal Article

Journal Name:: Biochemical and Biophysical Research Communications

Additional Journal Information:: Journal Volume: 357; Journal Issue: 4; Other Information: DOI: 10.1016/j.bbrc.2007.04.063; PII: S0006-291X(07)00790-5; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; CHROMOSOMES; DIABETES MELLITUS; DISEASES; GENES; GENETICS; PROTEINS

Citation Formats


                    Takeuchi, F, Yanai, K, Inomata, H, Kuzuya, N, Kajio, H, Honjo, S, Takeda, N, Kaburagi, Y, Yasuda, K, Shirasawa, S, Sasazuki, T, and Kato, N. Search of type 2 diabetes susceptibility gene on chromosome 20q.  United States: N. p., 2007. 
        Web.  doi:10.1016/j.bbrc.2007.04.063.

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                    Takeuchi, F, Yanai, K, Inomata, H, Kuzuya, N, Kajio, H, Honjo, S, Takeda, N, Kaburagi, Y, Yasuda, K, Shirasawa, S, Sasazuki, T, & Kato, N. Search of type 2 diabetes susceptibility gene on chromosome 20q.  United States.  https://doi.org/10.1016/j.bbrc.2007.04.063

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                    Takeuchi, F, Yanai, K, Inomata, H, Kuzuya, N, Kajio, H, Honjo, S, Takeda, N, Kaburagi, Y, Yasuda, K, Shirasawa, S, Sasazuki, T, and Kato, N. 2007.  
        "Search of type 2 diabetes susceptibility gene on chromosome 20q".  United States.  https://doi.org/10.1016/j.bbrc.2007.04.063.

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@article{osti_20991390,

  title        = {Search of type 2 diabetes susceptibility gene on chromosome 20q},

  author       = {Takeuchi, F and Yanai, K and Inomata, H and Kuzuya, N and Kajio, H and Honjo, S and Takeda, N and Kaburagi, Y and Yasuda, K and Shirasawa, S and Sasazuki, T and Kato, N},

  abstractNote = {Significant evidence of linkage to type 2 diabetes (T2D) has been shown in a relatively broad region on chromosome 20q, where the hepatocyte nuclear factor-4{alpha} (HNF4A) has been noted as a positional candidate. To systematically evaluate genetic susceptibility to T2D in the relevant region, we examined the disease association by using 1145 SNPs in two-step screening in the Japanese population. The marker screening enabled us to identify significant disease association in the lipopolysaccharide binding protein (LBP) but not in the HNF4A locus. In a 17.7-Mb interval screened, the strongest association was identified for a SNP, rs2232592, located in the intron of LBP, with an estimated odds ratio of 1.73 (95% CI 1.30-2.31) (P 0.0002) in the whole study panel involving 675 case and 474 control subjects. Our data suggest that the LBP gene may confer genetic susceptibility to T2D and this warrants further replication study.},

  doi          = {10.1016/j.bbrc.2007.04.063},

  url          = {https://www.osti.gov/biblio/20991390},
  journal      = {Biochemical and Biophysical Research Communications},

  issn         = {0006-291X},

  number       = 4,

  volume       = 357,

  place        = {United States},

  year         = {Fri Jun 15 00:00:00 EDT 2007},

  month        = {Fri Jun 15 00:00:00 EDT 2007}

}

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