Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma

Journal Article · Fri May 04 00:00:00 EDT 2007 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2007.02.130· OSTI ID:20991320

Gao, Juan ^[1]; Chen, Caiping ^[1]; Hong, Liu ^[1]; Wang, Jun ^[1]; Du, Yulei ^[1]; Song, Jiugang ^[1]; Shao, Xiaodong ^[1]; Zhang, Jing ^[1]; Han, Hua ^[2]; Liu, Jie ^[1]; Fan, Daiming ^[3]

---

1. Institute of Digestive Diseases, and State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province (China)
2. Department of Medical Genetics and Developmental Biology, and State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, Shaanxi Province (China)
3. Ins. of Digestive Diseases, and State Key Lab. of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province (China)

Jagged1 is one of the ligands of Notch signaling pathway, which controls cellular proliferation and differentiation, and also plays important roles in various malignant tumors. However, the expression of Jagged1 in hepatocellular carcinoma (HCC) has not been elucidated, nor whether it is associated with hepatitis B virus X protein (HBx). In this study, we found that Jagged1 was highly expressed in 79.2% (42/53) of HCC tissues compared with adjacent nontumor liver (P < 0.05), and its expression was found to be closely related with HBx (rs = 0.522, P < 0.001) in HCC tissues. Our in vitro study also showed that alteration of HBx expression in HCC cell lines led to a consistent change of Jagged1. Moreover, Jagged1 was found to co-localize and directly interact with HBx in HCC tissues and HBx expressed HCC cell lines. Our results reveal that Jagged1, which is regulated by HBx, may contribute to the development of HCC.

• OSTI ID: 20991320
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 356, Issue 2; Other Information: DOI: 10.1016/j.bbrc.2007.02.130; PII: S0006-291X(07)00355-5; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CELL PROLIFERATION
HEPATITIS
HEPATOMAS
IN VITRO
LIGANDS
LIVER
PROTEINS
VIRUSES