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Title: Tumour-initiating cells vs. cancer 'stem' cells and CD133: What's in the name?

Recent evidence suggests that a subset of cells within a tumour have 'stem-like' characteristics. These tumour-initiating cells, distinct from non-malignant stem cells, show low proliferative rates, high self-renewing capacity, propensity to differentiate into actively proliferating tumour cells, resistance to chemotherapy or radiation, and they are often characterised by elevated expression of the stem cell surface marker CD133. Understanding the molecular biology of the CD133{sup +} cancer cells is now essential for developing more effective cancer treatments. These may include drugs targeting organelles, such as mitochondria or lysosomes, using highly efficient and selective inducers of apoptosis. Alternatively, agents or treatment regimens that enhance sensitivity of these therapy-resistant 'tumour stem cells' to the current or emerging anti-tumour drugs would be of interest as well.
Authors:
 [1] ;  [2] ; ;  [1] ;  [1] ;  [2] ;  [3] ;  [1] ;  [1] ;  [2] ;  [1] ;  [4] ;  [5]
  1. Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Qld (Australia)
  2. (Czech Republic)
  3. Molecular Therapy Group, Institute of Molecular Genetics, Czech Academy of Sciences, Prague (Czech Republic)
  4. Laboratory of Apoptosis and Cell Signalling, Institute of Molecular Genetics, Czech Academy of Sciences, Prague (Czech Republic)
  5. Genomics Research Centre, School of Medical Science, Griffith University, Southport, Qld (Australia)
Publication Date:
OSTI Identifier:
20979878
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 355; Journal Issue: 4; Other Information: DOI: 10.1016/j.bbrc.2007.01.159; PII: S0006-291X(07)00232-X; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; APOPTOSIS; CHEMOTHERAPY; DRUGS; LYSOSOMES; MITOCHONDRIA; MOLECULAR BIOLOGY; NEOPLASMS; STEM CELLS