Invertebrate lamins
- Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904 (Israel)
- Division of Electron Microscopy, Biocenter of the University Am Hubland, D-97074 Wuerzburg (Germany)
Lamins are the main component of the nuclear lamina and considered to be the ancestors of all intermediate filament proteins. They are localized mainly at the nuclear periphery where they form protein complexes with integral proteins of the nuclear inner membrane, transcriptional regulators, histones and chromatin modifiers. Studying lamins in invertebrate species has unique advantages including the smaller number of lamin genes in the invertebrate genomes and powerful genetic analyses in Caenorhabditis elegans and Drosophila melanogaster. These simpler nuclear lamina systems allow direct analyses of their structure and functions. Here we give an overview of recent advances in the field of invertebrate nuclear lamins with special emphasis on their evolution, assembly and functions.
- OSTI ID:
- 20955482
- Journal Information:
- Experimental Cell Research, Vol. 313, Issue 10; Other Information: DOI: 10.1016/j.yexcr.2007.03.004; PII: S0014-4827(07)00107-3; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0014-4827
- Country of Publication:
- United States
- Language:
- English
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