skip to main content

Title: Long-Term Follow-up of Acoustic Schwannoma Radiosurgery With Marginal Tumor Doses of 12 to 13 Gy

Purpose: To define long-term tumor control and clinical outcomes of radiosurgery with marginal tumor doses of 12 to 13 Gy for unilateral acoustic schwannoma. Methods and Materials: A total of 216 patients with previously untreated unilateral acoustic schwannoma underwent Gamma Knife radiosurgery between 1992 and 2000 with marginal tumor doses of 12 to 13 Gy (median, 13 Gy). Median follow-up was 5.7 years (maximum, 12 years; 41 patients with >8 years). Treatment volumes were 0.08-37.5 cm{sup 3} (median, 1.3 cm{sup 3}). Results: The 10-year actuarial resection-free control rate was 98.3% {+-} 1.0%. Three patients required tumor resection: 2 for tumor growth and 1 partial resection for an enlarging adjacent subarachnoid cyst. Among 121 hearing patients with >3 years of follow-up, crude hearing preservation rates were 71% for keeping the same Gardner-Robertson hearing level, 74% for serviceable hearing, and 95% for any testable hearing. For 25 of these patients with intracanalicular tumors, the respective rates for preserving the same Gardner-Robertson level, serviceable hearing, and testable hearing were 80%, 88%, and 96%. Ten-year actuarial rates for preserving the same Gardner-Robertson hearing levels, serviceable hearing, any testable hearing, and unchanged facial and trigeminal nerve function were 44.0% {+-} 11.7%, 44.5% {+-} 10.5%, 85.3%more » {+-} 6.2%, 100%, and 94.9% {+-} 1.8%, respectively. Conclusions: Acoustic schwannoma radiosurgery with 12 to 13 Gy provides high rates of long-term tumor control and cranial nerve preservation after long-term follow-up.« less
Authors:
 [1] ;  [1] ;  [2] ;  [2] ;  [3] ;  [2] ;  [1] ;  [2] ;  [2] ;  [2] ;  [4]
  1. Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States)
  2. (United States)
  3. Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States)
  4. Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States) and Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States). E-mail: flickingerjc@upmc.edu
Publication Date:
OSTI Identifier:
20951714
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 68; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2007.01.001; PII: S0360-3016(07)00110-1; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AUDITORY ORGANS; CARCINOMAS; CYSTS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; SURGERY