Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis
Abstract
The authors assessed the gene polymorphisms of missense C/T polymorphism in exon 6 of the urokinase-plasminogen activator (PLAU) gene (PLAU P141L), A/u-repeat in intron 8 of the tissue-type plasminogen activator (PLAT) gene (PLAT TPA25 Alu insertion), and 4G/5G in the promoter region of the serine proteinase inhibitor, clade E (SERPINE) or plasminogen activator inhibitor type 1 gene (SERPINE1 -675 4G/5G) in 153 healthy volunteers and 154 retired coal miners with coal miners' pneumoconiosis (CWP). The CWP subjects included 94 individuals with simple pneumoconiosis and 60 individuals with progressive massive fibrosis presenting with worse pulmonary function. The distributions of genotypes of these three genes did not differ between the control and CWP subjects or between subjects with simple pneumoconiosis and those with progressive massive fibrosis. However, by assessing duration of work and its interaction with genotypes by means of logistic regression, the authors found the missense C/T polymorphism in exon 6 of the PLAU gene to be an effect modifier of the association between work duration and the development of progressive massive fibrosis.
- Authors:
-
- Chang Gung Memorial Hospital, Chilung (Taiwan)
- Publication Date:
- OSTI Identifier:
- 20947424
- Resource Type:
- Journal Article
- Journal Name:
- Archives of Environmental Health
- Additional Journal Information:
- Journal Volume: 61; Journal Issue: 2; Journal ID: ISSN 0003-9896
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 01 COAL, LIGNITE, AND PEAT; PNEUMOCONIOSES; COAL MINERS; FIBROSIS; LUNGS; GENES; ENZYMES; GENOTYPE
Citation Formats
Chang, L C, Tseng, J C, Hua, C C, Liu, Y C, Shieh, W B, and Wu, H P. Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis. United States: N. p., 2006.
Web. doi:10.3200/AEOH.61.2.61-66.
Chang, L C, Tseng, J C, Hua, C C, Liu, Y C, Shieh, W B, & Wu, H P. Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis. United States. https://doi.org/10.3200/AEOH.61.2.61-66
Chang, L C, Tseng, J C, Hua, C C, Liu, Y C, Shieh, W B, and Wu, H P. 2006.
"Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis". United States. https://doi.org/10.3200/AEOH.61.2.61-66.
@article{osti_20947424,
title = {Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis},
author = {Chang, L C and Tseng, J C and Hua, C C and Liu, Y C and Shieh, W B and Wu, H P},
abstractNote = {The authors assessed the gene polymorphisms of missense C/T polymorphism in exon 6 of the urokinase-plasminogen activator (PLAU) gene (PLAU P141L), A/u-repeat in intron 8 of the tissue-type plasminogen activator (PLAT) gene (PLAT TPA25 Alu insertion), and 4G/5G in the promoter region of the serine proteinase inhibitor, clade E (SERPINE) or plasminogen activator inhibitor type 1 gene (SERPINE1 -675 4G/5G) in 153 healthy volunteers and 154 retired coal miners with coal miners' pneumoconiosis (CWP). The CWP subjects included 94 individuals with simple pneumoconiosis and 60 individuals with progressive massive fibrosis presenting with worse pulmonary function. The distributions of genotypes of these three genes did not differ between the control and CWP subjects or between subjects with simple pneumoconiosis and those with progressive massive fibrosis. However, by assessing duration of work and its interaction with genotypes by means of logistic regression, the authors found the missense C/T polymorphism in exon 6 of the PLAU gene to be an effect modifier of the association between work duration and the development of progressive massive fibrosis.},
doi = {10.3200/AEOH.61.2.61-66},
url = {https://www.osti.gov/biblio/20947424},
journal = {Archives of Environmental Health},
issn = {0003-9896},
number = 2,
volume = 61,
place = {United States},
year = {Wed Mar 15 00:00:00 EST 2006},
month = {Wed Mar 15 00:00:00 EST 2006}
}