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Title: Cranial location of level II lymph nodes in laryngeal cancer: Implications for elective nodal target volume delineation

Abstract

Purpose: To analyze the cranial distribution of level II lymph nodes in patients with laryngeal cancer to optimize the elective radiation nodal target volume delineation. Methods and Materials: The most cranially located metastatic lymph node was delineated in 67 diagnostic CT data sets. The minimum distance from the base of the skull (BOS) to the lymph node was determined. Results: A total of 98 lymph nodes were delineated including 62 ipsilateral and 36 contralateral lymph nodes. The mean ipsilateral and contralateral distance from the top of the most cranial metastatic lymph node to the BOS was 36 mm (range, -9-120; standard deviation [SD], 17.9) and 35 mm (range, 14-78; SD 15.0), respectively. Only 5% and 12% of the ipsilateral and 3% and 9% of the contralateral metastatic lymph nodes were located within 15 mm and 20 mm below the BOS, respectively. No significant differences were found between patients with only ipsilateral metastatic lymph nodes and patients with bilateral metastatic lymph nodes. Between tumors that do cross the midline and those that do not, no significant difference was found in the distance of the most cranial lymph node to the BOS and the occurrence ipsilateral or contralateral. Conclusions: Setting the cranialmore » border of the nodal target volume 1.5 cm below the base of the skull covers 95% of the lymph nodes and should be considered in elective nodal irradiation for laryngeal cancer. Bilateral neck irradiation is mandatory, including patients with unilateral laryngeal cancer, when elective irradiation is advised.« less

Authors:
 [1];  [1];  [1]
  1. Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands)
Publication Date:
OSTI Identifier:
20944688
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 67; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2006.10.003; PII: S0360-3016(06)03242-1; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEAD; IRRADIATION; LYMPH NODES; METASTASES; NECK; NEOPLASMS; PATIENTS; RADIOTHERAPY; SKULL

Citation Formats

Braam, Petra M, Raaijmakers, Cornelis P.J., and Terhaard, Chris. Cranial location of level II lymph nodes in laryngeal cancer: Implications for elective nodal target volume delineation. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.10.003.
Braam, Petra M, Raaijmakers, Cornelis P.J., & Terhaard, Chris. Cranial location of level II lymph nodes in laryngeal cancer: Implications for elective nodal target volume delineation. United States. https://doi.org/10.1016/j.ijrobp.2006.10.003
Braam, Petra M, Raaijmakers, Cornelis P.J., and Terhaard, Chris. 2007. "Cranial location of level II lymph nodes in laryngeal cancer: Implications for elective nodal target volume delineation". United States. https://doi.org/10.1016/j.ijrobp.2006.10.003.
@article{osti_20944688,
title = {Cranial location of level II lymph nodes in laryngeal cancer: Implications for elective nodal target volume delineation},
author = {Braam, Petra M and Raaijmakers, Cornelis P.J. and Terhaard, Chris},
abstractNote = {Purpose: To analyze the cranial distribution of level II lymph nodes in patients with laryngeal cancer to optimize the elective radiation nodal target volume delineation. Methods and Materials: The most cranially located metastatic lymph node was delineated in 67 diagnostic CT data sets. The minimum distance from the base of the skull (BOS) to the lymph node was determined. Results: A total of 98 lymph nodes were delineated including 62 ipsilateral and 36 contralateral lymph nodes. The mean ipsilateral and contralateral distance from the top of the most cranial metastatic lymph node to the BOS was 36 mm (range, -9-120; standard deviation [SD], 17.9) and 35 mm (range, 14-78; SD 15.0), respectively. Only 5% and 12% of the ipsilateral and 3% and 9% of the contralateral metastatic lymph nodes were located within 15 mm and 20 mm below the BOS, respectively. No significant differences were found between patients with only ipsilateral metastatic lymph nodes and patients with bilateral metastatic lymph nodes. Between tumors that do cross the midline and those that do not, no significant difference was found in the distance of the most cranial lymph node to the BOS and the occurrence ipsilateral or contralateral. Conclusions: Setting the cranial border of the nodal target volume 1.5 cm below the base of the skull covers 95% of the lymph nodes and should be considered in elective nodal irradiation for laryngeal cancer. Bilateral neck irradiation is mandatory, including patients with unilateral laryngeal cancer, when elective irradiation is advised.},
doi = {10.1016/j.ijrobp.2006.10.003},
url = {https://www.osti.gov/biblio/20944688}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 67,
place = {United States},
year = {Thu Feb 01 00:00:00 EST 2007},
month = {Thu Feb 01 00:00:00 EST 2007}
}