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Title: Three-dimensional time-resolved optical mammography of the uncompressed breast

Abstract

Optical tomography is being developed as a means of detecting and specifying disease in the adult female breast. We present a series of clinical three-dimensional optical images obtained with a 32-channel time-resolvedsystem and a liquid-coupled interface. Patients place their breasts in a hemispherical cup to whichsources and detectors are coupled, and the remaining space is filled with a highly scattering fluid. Acohort of 38 patients has been scanned, with a variety of benign and malignant lesions. Images show that hypervascularization associated with tumors provides very high contrast due to increased absorption by hemoglobin. Only half of the fibroadenomas scanned could be observed, but of those that could bedetected, all but one revealed an apparent increase in blood volume and a decrease in scatter and oxygen saturation.

Authors:
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Publication Date:
OSTI Identifier:
20929749
Resource Type:
Journal Article
Journal Name:
Applied Optics
Additional Journal Information:
Journal Volume: 46; Journal Issue: 17; Other Information: DOI: 10.1364/AO.46.003628; (c) 2007 Optical Society of America; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0003-6935
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABSORPTION; ADULTS; BIOMEDICAL RADIOGRAPHY; BLOOD; HEMOGLOBIN; MAMMARY GLANDS; NEOPLASMS; OXYGEN; PATIENTS; THREE-DIMENSIONAL CALCULATIONS; TIME RESOLUTION; TOMOGRAPHY

Citation Formats

Enfield, Louise C, Gibson, Adam P, Everdell, Nicholas L, Delpy, David T, Schweiger, Martin, Arridge, Simon R, Richardson, Caroline, Keshtgar, Mohammad, Douek, Michael, and Hebden, Jeremy C. Three-dimensional time-resolved optical mammography of the uncompressed breast. United States: N. p., 2007. Web. doi:10.1364/AO.46.003628.
Enfield, Louise C, Gibson, Adam P, Everdell, Nicholas L, Delpy, David T, Schweiger, Martin, Arridge, Simon R, Richardson, Caroline, Keshtgar, Mohammad, Douek, Michael, & Hebden, Jeremy C. Three-dimensional time-resolved optical mammography of the uncompressed breast. United States. https://doi.org/10.1364/AO.46.003628
Enfield, Louise C, Gibson, Adam P, Everdell, Nicholas L, Delpy, David T, Schweiger, Martin, Arridge, Simon R, Richardson, Caroline, Keshtgar, Mohammad, Douek, Michael, and Hebden, Jeremy C. 2007. "Three-dimensional time-resolved optical mammography of the uncompressed breast". United States. https://doi.org/10.1364/AO.46.003628.
@article{osti_20929749,
title = {Three-dimensional time-resolved optical mammography of the uncompressed breast},
author = {Enfield, Louise C and Gibson, Adam P and Everdell, Nicholas L and Delpy, David T and Schweiger, Martin and Arridge, Simon R and Richardson, Caroline and Keshtgar, Mohammad and Douek, Michael and Hebden, Jeremy C},
abstractNote = {Optical tomography is being developed as a means of detecting and specifying disease in the adult female breast. We present a series of clinical three-dimensional optical images obtained with a 32-channel time-resolvedsystem and a liquid-coupled interface. Patients place their breasts in a hemispherical cup to whichsources and detectors are coupled, and the remaining space is filled with a highly scattering fluid. Acohort of 38 patients has been scanned, with a variety of benign and malignant lesions. Images show that hypervascularization associated with tumors provides very high contrast due to increased absorption by hemoglobin. Only half of the fibroadenomas scanned could be observed, but of those that could bedetected, all but one revealed an apparent increase in blood volume and a decrease in scatter and oxygen saturation.},
doi = {10.1364/AO.46.003628},
url = {https://www.osti.gov/biblio/20929749}, journal = {Applied Optics},
issn = {0003-6935},
number = 17,
volume = 46,
place = {United States},
year = {Sun Jun 10 00:00:00 EDT 2007},
month = {Sun Jun 10 00:00:00 EDT 2007}
}