Weight-dependent changes of immune system in adipose tissue: Importance of leptin

Journal Article · Sat Jul 15 00:00:00 EDT 2006 · Experimental Cell Research

DOI:https://doi.org/10.1016/j.yexcr.2006.03.023· OSTI ID:20857997

Caspar-Bauguil, S ^[1]; Cousin, B ^[1]; Andre, M ^[1]; Nibbelink, M ^[1]; Galinier, A ^[1]; Periquet, B ^[2]; Casteilla, L ^[1]; Penicaud, L ^[1]

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1. UMR 5018 CNRS-UPS, IFR 31, CHU Rangueil, TSA 50032, 31059 Toulouse Cedex 9 (France)
2. Groupe de Recherche et d'Etude en Nutrition (GREEN), Laboratoire de Biochimie Generale et Nutritionnelle, Place du Docteur Baylac, CHU Purpan, TSA 40031, 31059 Toulouse Cedex 9 (France)

Ancestral lymphoid cells reside in adipose tissues, and their numbers are highly altered in obesity. Leptin, production of which is correlated to fat mass, is strongly involved in the relationships between adipose tissues and immune system. We investigated in epididymal (EPI) and inguinal (ING) fat pads to determine whether 1) lymphocyte phenotypes were correlated to the tissue weight and 2) leptin was involved in such relationships. Immunohistological analyses revealed a tight relationship between the T and NK lymphocytes of the stromal vascular fraction and adipocytes. We identified a significant negative and positive correlation between EPI weight and the percentage of NK and total T cells respectively by cytofluorometric analyses. The NK and ancestral {gamma}{delta} T cell contents were directly dependent of leptin since they increased significantly in high-fat (HF) diet mice but not in leptin-deficient (ob/ob) mice as compared to control. By contrast, the {alpha}{beta} T cell content seemed independent of leptin because their percentages increased significantly with the EPI weight whatever the type of mice (control, HF, ob/ob). The present study suggests that adipose tissues present, according to their localization, different immunological mechanisms that might be involved in the regulation of adipose cells functions and proliferations.

• OSTI ID: 20857997
• Journal Information: Experimental Cell Research, Vol. 312, Issue 12; Other Information: DOI: 10.1016/j.yexcr.2006.03.023; PII: S0014-4827(06)00111-X; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0014-4827
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ADIPOSE TISSUE
FATS
HYDROFLUORIC ACID
LEPTIN
LYMPHOCYTES
METABOLIC DISEASES
MICE
NATURAL KILLER CELLS
PHENOTYPE