Kv1.3/Kv1.5 heteromeric channels compromise pharmacological responses in macrophages
- Molecular Physiology Laboratory, Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avda. Diagonal 645, E-08028 Barcelona (Spain)
- Departament de Patologia i Terapeutica Experimental, Universitat de Barcelona-Campus de Bellvitge, E-08907 Hospitalet de Llobregat (Spain)
- Institut de Recerca Biomedica, Parc Cientific de Barcelona, Universitat de Barcelona, E-08028 Barcelona (Spain)
Voltage-dependent K{sup +} (Kv) channels are involved in the immune response. Kv1.3 is highly expressed in activated macrophages and T-effector memory cells of autoimmune disease patients. Macrophages are actively involved in T-cell activation by cytokine production and antigen presentation. However, unlike T-cells, macrophages express Kv1.5, which is resistant to Kv1.3-drugs. We demonstrate that mononuclear phagocytes express different Kv1.3/Kv1.5 ratios, leading to biophysically and pharmacologically distinct channels. Therefore, Kv1.3-based treatments to alter physiological responses, such as proliferation and activation, are impaired by Kv1.5 expression. The presence of Kv1.5 in the macrophagic lineage should be taken into account when designing Kv1.3-based therapies.
- OSTI ID:
- 20857973
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 352, Issue 4; Other Information: DOI: 10.1016/j.bbrc.2006.11.120; PII: S0006-291X(06)02604-0; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10
The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter