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Title: Simulation study of respiratory-induced errors in cardiac positron emission tomography/computed tomography

Abstract

Heart disease is a leading killer in Canada and positron emission tomography (PET) provides clinicians with in vivo metabolic information for diagnosing heart disease. Transmission data are usually acquired with {sup 68}Ge, although the advent of PET/CT scanners has made computed tomography (CT) an alternative option. The fast data acquisition of CT compared to PET may cause potential misregistration problems, leading to inaccurate attenuation correction (AC). Using Monte Carlo simulations and an anthropomorphic dynamic computer phantom, this study determines the magnitude and location of respiratory-induced errors in radioactivity uptake measured in cardiac PET/CT. A homogeneous tracer distribution in the heart was considered. The AC was based on (1) a time-averaged attenuation map (2) CT maps from a single phase of the respiratory cycle, and (3) CT maps phase matched to the emission data. Circumferential profiles of the heart uptake were compared and differences of up to 24% were found between the single-phase CT-AC method and the true phantom values. Simulation results were supported by a PET/CT canine study which showed differences of up to 10% in the heart uptake in the lung-heart boundary region when comparing {sup 68}Ge- to CT-based AC with the CT map acquired at end inhalation.

Authors:
;  [1]
  1. Department of Nuclear Medicine London, Lawson Health Research Institute, St. Joseph's Health Care, London, Ontario, N6A 4V2 (Canada) and University of Western Ontario, London, Ontario, N6A 5B8 (Canada)
Publication Date:
OSTI Identifier:
20853388
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 33; Journal Issue: 8; Other Information: DOI: 10.1118/1.2211708; (c) 2006 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ATTENUATION; CARDIOVASCULAR DISEASES; COMPUTERIZED SIMULATION; CORRECTIONS; DATA ACQUISITION; DATA TRANSMISSION; DOGS; ERRORS; GERMANIUM 68; HEART; IN VIVO; INHALATION; LUNGS; MONTE CARLO METHOD; PHANTOMS; POSITRON COMPUTED TOMOGRAPHY; RADIOACTIVITY; UPTAKE

Citation Formats

Fitzpatrick, Gianna M, and Wells, R Glenn. Simulation study of respiratory-induced errors in cardiac positron emission tomography/computed tomography. United States: N. p., 2006. Web. doi:10.1118/1.2211708.
Fitzpatrick, Gianna M, & Wells, R Glenn. Simulation study of respiratory-induced errors in cardiac positron emission tomography/computed tomography. United States. https://doi.org/10.1118/1.2211708
Fitzpatrick, Gianna M, and Wells, R Glenn. 2006. "Simulation study of respiratory-induced errors in cardiac positron emission tomography/computed tomography". United States. https://doi.org/10.1118/1.2211708.
@article{osti_20853388,
title = {Simulation study of respiratory-induced errors in cardiac positron emission tomography/computed tomography},
author = {Fitzpatrick, Gianna M and Wells, R Glenn},
abstractNote = {Heart disease is a leading killer in Canada and positron emission tomography (PET) provides clinicians with in vivo metabolic information for diagnosing heart disease. Transmission data are usually acquired with {sup 68}Ge, although the advent of PET/CT scanners has made computed tomography (CT) an alternative option. The fast data acquisition of CT compared to PET may cause potential misregistration problems, leading to inaccurate attenuation correction (AC). Using Monte Carlo simulations and an anthropomorphic dynamic computer phantom, this study determines the magnitude and location of respiratory-induced errors in radioactivity uptake measured in cardiac PET/CT. A homogeneous tracer distribution in the heart was considered. The AC was based on (1) a time-averaged attenuation map (2) CT maps from a single phase of the respiratory cycle, and (3) CT maps phase matched to the emission data. Circumferential profiles of the heart uptake were compared and differences of up to 24% were found between the single-phase CT-AC method and the true phantom values. Simulation results were supported by a PET/CT canine study which showed differences of up to 10% in the heart uptake in the lung-heart boundary region when comparing {sup 68}Ge- to CT-based AC with the CT map acquired at end inhalation.},
doi = {10.1118/1.2211708},
url = {https://www.osti.gov/biblio/20853388}, journal = {Medical Physics},
issn = {0094-2405},
number = 8,
volume = 33,
place = {United States},
year = {Tue Aug 15 00:00:00 EDT 2006},
month = {Tue Aug 15 00:00:00 EDT 2006}
}