Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production
Abstract
In this study, we investigated the effect of the aqueous extract of Mosla dianthera (Maxim.) (AEMD) on the mast cell-mediated allergy model and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as asthma, sinusitis and rheumatoid arthritis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. AEMD inhibited compound 48/80-induced systemic reactions in mice. AEMD decreased immunoglobulin E-mediated local allergic reactions, passive cutaneous anaphylaxis. AEMD attenuated intracellular calcium level and release of histamine from rat peritoneal mast cells activated by compound 48/80. Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-{alpha}, IL-8 and IL-6 secretion in human mast cells. The inhibitory effect of AEMD on the pro-inflammatory cytokines was nuclear factor-{kappa}B (NF-{kappa}B) dependent. AEMD decreased PMA and A23187-induced degradation of I{kappa}B{alpha} and nuclear translocation of NF-{kappa}B. Our findings provide evidence that AEMD inhibits mast cell-derived immediate-type allergic reactions and involvement of pro-inflammatory cytokines and NF-{kappa}B in these effects.
- Authors:
-
- College of Pharmacy, Woosuk University, Jeonju 565-701 (Korea, Republic of)
- Department of Pharmacology, Kyungpook National University Medical School, Daegu 700-422 (Korea, Republic of)
- Publication Date:
- OSTI Identifier:
- 20850469
- Resource Type:
- Journal Article
- Journal Name:
- Toxicology and Applied Pharmacology
- Additional Journal Information:
- Journal Volume: 216; Journal Issue: 3; Other Information: DOI: 10.1016/j.taap.2006.06.007; PII: S0041-008X(06)00217-1; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; ACETATES; ALLERGY; ANAPHYLAXIS; ASTHMA; CALCIUM; DRUGS; HISTAMINE; IMMUNOGLOBULINS; INFLAMMATION; INHIBITION; LYMPHOKINES; MAST CELLS; MICE; PUBLIC HEALTH; RATS; RHEUMATIC DISEASES; SECRETION; TRANSLOCATION
Citation Formats
Lee, Dong-Hee, Kim, Sang-Hyun, Eun, Jae-Soon, and Shin, Tae-Yong. Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production. United States: N. p., 2006.
Web. doi:10.1016/j.taap.2006.06.007.
Lee, Dong-Hee, Kim, Sang-Hyun, Eun, Jae-Soon, & Shin, Tae-Yong. Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production. United States. https://doi.org/10.1016/j.taap.2006.06.007
Lee, Dong-Hee, Kim, Sang-Hyun, Eun, Jae-Soon, and Shin, Tae-Yong. 2006.
"Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production". United States. https://doi.org/10.1016/j.taap.2006.06.007.
@article{osti_20850469,
title = {Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production},
author = {Lee, Dong-Hee and Kim, Sang-Hyun and Eun, Jae-Soon and Shin, Tae-Yong},
abstractNote = {In this study, we investigated the effect of the aqueous extract of Mosla dianthera (Maxim.) (AEMD) on the mast cell-mediated allergy model and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as asthma, sinusitis and rheumatoid arthritis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. AEMD inhibited compound 48/80-induced systemic reactions in mice. AEMD decreased immunoglobulin E-mediated local allergic reactions, passive cutaneous anaphylaxis. AEMD attenuated intracellular calcium level and release of histamine from rat peritoneal mast cells activated by compound 48/80. Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-{alpha}, IL-8 and IL-6 secretion in human mast cells. The inhibitory effect of AEMD on the pro-inflammatory cytokines was nuclear factor-{kappa}B (NF-{kappa}B) dependent. AEMD decreased PMA and A23187-induced degradation of I{kappa}B{alpha} and nuclear translocation of NF-{kappa}B. Our findings provide evidence that AEMD inhibits mast cell-derived immediate-type allergic reactions and involvement of pro-inflammatory cytokines and NF-{kappa}B in these effects.},
doi = {10.1016/j.taap.2006.06.007},
url = {https://www.osti.gov/biblio/20850469},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 3,
volume = 216,
place = {United States},
year = {Wed Nov 01 00:00:00 EST 2006},
month = {Wed Nov 01 00:00:00 EST 2006}
}