TESS-based dose-response using pediatric clonidine exposures

Journal Article · Thu Jun 01 00:00:00 EDT 2006 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2005.10.009· OSTI ID:20850336

Benson, Blaine E ^[1]; Spyker, Daniel A ^[2]; Troutman, William G ^[3]; Watson, William A ^[4]

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1. New Mexico Poison and Drug Information Center and University of New Mexico College of Pharmacy, Albuquerque, NM 87131 (United States)
2. Alexza Pharmaceuticals, Palo Alto, CA 94303 (United States)
3. University of New Mexico College of Pharmacy, Albuquerque, NM 87131 (United States)
4. American Association of Poison Control Centers, Washington, DC 20016 (United States)

Objective: The toxic and lethal doses of clonidine in children are unclear. This study was designed to determine whether data from the American Association of Poison Control Centers Toxic Exposure Surveillance System (TESS) could be utilized to determine a dose-response relationship for pediatric clonidine exposure. Methods: 3458 single-substance clonidine exposures in children <6 years of age reported to TESS from January 2000 through December 2003 were examined. Dose ingested, age, and medical outcome were available for 1550 cases. Respiratory arrest cases (n = 8) were classified as the most severe of the medical outcome categories (Arrest, Major, Moderate, Mild, and No effect). Exposures reported as a 'taste or lick' (n = 51) were included as a dose of 1/10 of the dosage form involved. Dose ranged from 0.4 to 1980 (median 13) {mu}g/kg. Weight was imputed based on a quadratic estimate of weight for age. Dose certainty was coded as exact (26% of cases) or not exact (74%). Medical outcome (response) was examined via logistic regression using SAS JMP (release 5.1). Results: The logistic model describing medical outcome (P < 0.0001) included Log dose/kg (P 0.0000) and Certainty (P = 0.045). Conclusion: TESS data can provide the basis for a statistically sound description of dose-response for pediatric clonidine poisoning exposures.

• OSTI ID: 20850336
• Journal Information: Toxicology and Applied Pharmacology, Vol. 213, Issue 2; Other Information: DOI: 10.1016/j.taap.2005.10.009; PII: S0041-008X(05)00601-0; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CHILDREN
DOSE-RESPONSE RELATIONSHIPS
DRUGS
LETHAL DOSES
POISONING