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Title: The impact of axillary lymph nodes removed in staging of node-positive breast carcinoma

Abstract

Purpose: Number of positive lymph nodes in the axilla and pathologic lymph node status (pN) have a great impact on staging according to the current American Joint Committee on Cancer staging system of breast carcinoma. Our aim was to define whether the total number of removed axillary lymph nodes influences the pN and thus the staging. Methods and Materials: The records of 798 consecutive invasive breast cancer patients with T1-3 tumors and positive axillary lymph nodes who underwent modified radical mastectomy between 1999 and 2005 in our hospital were reviewed. The total number of removed nodes were grouped, and compared with the patient and tumor characteristics and the influence of the number of nodes removed on the staging was analyzed. Results: The proportion of patients with {>=}4 positive nodes (59%), and pN3 status (51%) were the highest in the group with 21-25 nodes removed. Compared with patients with 1-20 nodes removed, the proportion of patients with {>=}4 positive nodes (52%), and pN3 status (46%) were significantly higher in those with more than 20 nodes removed. Although the proportion of Stage IIA and IIB decreased, the proportion of Stage IIIA and IIIC increased in patients with >20 nodes removed compared withmore » those with 1-20 nodes removed. Conclusions: In patients with axillary node-positive breast carcinoma, staging is highly influenced by total number of removed nodes. Levels I-III axillary dissection with more than 20 axillary lymph nodes removed could lead to more effective adjuvant chemotherapy and increases substantially the proportion of patients to receive radiotherapy.« less

Authors:
 [1];  [1]
  1. Department of General Surgery, Ankara Oncology Education and Research Hospital, Ankara (Turkey)
Publication Date:
OSTI Identifier:
20850253
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 66; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2006.07.015; PII: S0360-3016(06)01254-5; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; CHEMOTHERAPY; HOSPITALS; LYMPH NODES; MAMMARY GLANDS; PATIENTS; RADIOTHERAPY

Citation Formats

Kuru, Bekir, and Bozgul, Mustafa. The impact of axillary lymph nodes removed in staging of node-positive breast carcinoma. United States: N. p., 2006. Web. doi:10.1016/j.ijrobp.2006.07.015.
Kuru, Bekir, & Bozgul, Mustafa. The impact of axillary lymph nodes removed in staging of node-positive breast carcinoma. United States. https://doi.org/10.1016/j.ijrobp.2006.07.015
Kuru, Bekir, and Bozgul, Mustafa. 2006. "The impact of axillary lymph nodes removed in staging of node-positive breast carcinoma". United States. https://doi.org/10.1016/j.ijrobp.2006.07.015.
@article{osti_20850253,
title = {The impact of axillary lymph nodes removed in staging of node-positive breast carcinoma},
author = {Kuru, Bekir and Bozgul, Mustafa},
abstractNote = {Purpose: Number of positive lymph nodes in the axilla and pathologic lymph node status (pN) have a great impact on staging according to the current American Joint Committee on Cancer staging system of breast carcinoma. Our aim was to define whether the total number of removed axillary lymph nodes influences the pN and thus the staging. Methods and Materials: The records of 798 consecutive invasive breast cancer patients with T1-3 tumors and positive axillary lymph nodes who underwent modified radical mastectomy between 1999 and 2005 in our hospital were reviewed. The total number of removed nodes were grouped, and compared with the patient and tumor characteristics and the influence of the number of nodes removed on the staging was analyzed. Results: The proportion of patients with {>=}4 positive nodes (59%), and pN3 status (51%) were the highest in the group with 21-25 nodes removed. Compared with patients with 1-20 nodes removed, the proportion of patients with {>=}4 positive nodes (52%), and pN3 status (46%) were significantly higher in those with more than 20 nodes removed. Although the proportion of Stage IIA and IIB decreased, the proportion of Stage IIIA and IIIC increased in patients with >20 nodes removed compared with those with 1-20 nodes removed. Conclusions: In patients with axillary node-positive breast carcinoma, staging is highly influenced by total number of removed nodes. Levels I-III axillary dissection with more than 20 axillary lymph nodes removed could lead to more effective adjuvant chemotherapy and increases substantially the proportion of patients to receive radiotherapy.},
doi = {10.1016/j.ijrobp.2006.07.015},
url = {https://www.osti.gov/biblio/20850253}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 66,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 2006},
month = {Fri Dec 01 00:00:00 EST 2006}
}