Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy

Braam, Petra M; Roesink, Judith M; Raaijmakers, Cornelis P.J.

doi:10.1016/j.ijrobp.2006.06.045

Title: Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy

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Abstract

Purpose: Xerostomia is a severe complication after radiotherapy for oropharyngeal cancer, as the salivary glands are in close proximity with the primary tumor. Intensity-modulated radiotherapy (IMRT) offers theoretical advantages for normal tissue sparing. A Phase II study was conducted to determine the value of IMRT for salivary output preservation compared with conventional radiotherapy (CRT). Methods and Materials: A total of 56 patients with oropharyngeal cancer were prospectively evaluated. Of these, 30 patients were treated with IMRT and 26 with CRT. Stimulated parotid salivary flow was measured before, 6 weeks, and 6 months after treatment. A complication was defined as a stimulated parotid flow rate <25% of the preradiotherapy flow rate. Results: The mean dose to the parotid glands was 48.1 Gy (SD 14 Gy) for CRT and 33.7 Gy (SD 10 Gy) for IMRT (p < 0.005). The mean parotid flow ratio 6 weeks and 6 months after treatment was respectively 41% and 64% for IMRT and respectively 11% and 18% for CRT. As a result, 6 weeks after treatment, the number of parotid flow complications was significantly lower after IMRT (55%) than after CRT (87%) (p = 0.002). The number of complications 6 months after treatment was 56% formore »« less

Authors:

Braam, Petra M ^[1]; Roesink, Judith M ^[1]; Raaijmakers, Cornelis P.J. ^[1]

Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands)

Publication Date:: Wed Nov 15 00:00:00 EST 2006

OSTI Identifier:: 20850210

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 66; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2006.06.045; PII: S0360-3016(06)01112-6; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; FLOW RATE; HEAD; NECK; PATIENTS; RADIATION DOSES; RADIOTHERAPY; SALIVARY GLANDS

Citation Formats


                    Braam, Petra M, Terhaard, Chris H.J. M.D., Roesink, Judith M, and Raaijmakers, Cornelis P.J. Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy.  United States: N. p., 2006. 
        Web.  doi:10.1016/j.ijrobp.2006.06.045.

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                    Braam, Petra M, Terhaard, Chris H.J. M.D., Roesink, Judith M, & Raaijmakers, Cornelis P.J. Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy.  United States.  https://doi.org/10.1016/j.ijrobp.2006.06.045

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                    Braam, Petra M, Terhaard, Chris H.J. M.D., Roesink, Judith M, and Raaijmakers, Cornelis P.J. 2006.  
        "Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy".  United States.  https://doi.org/10.1016/j.ijrobp.2006.06.045.

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@article{osti_20850210,

  title        = {Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy},

  author       = {Braam, Petra M and Terhaard, Chris H.J. M.D. and Roesink, Judith M and Raaijmakers, Cornelis P.J.},

  abstractNote = {Purpose: Xerostomia is a severe complication after radiotherapy for oropharyngeal cancer, as the salivary glands are in close proximity with the primary tumor. Intensity-modulated radiotherapy (IMRT) offers theoretical advantages for normal tissue sparing. A Phase II study was conducted to determine the value of IMRT for salivary output preservation compared with conventional radiotherapy (CRT). Methods and Materials: A total of 56 patients with oropharyngeal cancer were prospectively evaluated. Of these, 30 patients were treated with IMRT and 26 with CRT. Stimulated parotid salivary flow was measured before, 6 weeks, and 6 months after treatment. A complication was defined as a stimulated parotid flow rate <25% of the preradiotherapy flow rate. Results: The mean dose to the parotid glands was 48.1 Gy (SD 14 Gy) for CRT and 33.7 Gy (SD 10 Gy) for IMRT (p < 0.005). The mean parotid flow ratio 6 weeks and 6 months after treatment was respectively 41% and 64% for IMRT and respectively 11% and 18% for CRT. As a result, 6 weeks after treatment, the number of parotid flow complications was significantly lower after IMRT (55%) than after CRT (87%) (p = 0.002). The number of complications 6 months after treatment was 56% for IMRT and 81% for CRT (p = 0.04). Conclusions: IMRT significantly reduces the number of parotid flow complications for patients with oropharyngeal cancer.},

  doi          = {10.1016/j.ijrobp.2006.06.045},

  url          = {https://www.osti.gov/biblio/20850210},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 4,

  volume       = 66,

  place        = {United States},

  year         = {Wed Nov 15 00:00:00 EST 2006},

  month        = {Wed Nov 15 00:00:00 EST 2006}

}

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